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[Preprint]. 2025 Jun 5:2025.04.27.650697. [Version 3] doi: 10.1101/2025.04.27.650697

Figure 1. Pri-PCa shows concordant increases of AR-A and Stemness and both are decreased by nADT.

Figure 1.

A-C, PCa has increased AR-A as well as the Stemness compared to matched benign tissues. Pairwise comparisons of AR mRNA levels, canonical AR-A, and Stemness scores showing significant increases in primary tumors (T) as compared to the matched adjacent benign prostate tissues (N) from the same individual in TCGA-PRAD cohort (n=51; A), and Wyatt 2014 cohort (n=12; B). In the Long 2020 cohort (n=10; C), increases in AR-A and Stemness reached statistical significance whereas the increase in AR mRNA levels approached statistical significance (P = 0.06).

D-F, nADT decreases both AR-A and Stemness. Pairwise comparison of AR mRNA levels, AR-A, and Stemness showing significant decrease of both AR-A and Stemness after nADT (Post-nADT) as compared to the matched samples before nADT (Pre-nADT) from the same individual (D, Rajan 2014 cohort; E, Sharma 2018 cohort; F, Long 2020 cohort).

In all plots, sample sizes are indicated (see also Supplementary Table S1 for cohort and RNA-seq data access information). Within the plots, results are shown as the mean ± SD and pairs are linked with a grey line. Significance was calculated by two-tailed paired Student’s t-test (ns, not significant; *, P < 0.05; **, P < 0.01; ***, P < 0.001; ****, P < 0.0001).