The editors are publishing this note to alert readers to a concern about this article (1). The authors communicated that an RNA-seq replicate affected by a technical issue was inadvertently included in the original analyses and in the GEO submission (GSE185091), and the number of differentially expressed genes induced by the ENL inhibitor was underestimated in the original analysis due to the inclusion of this problematic replicate. The authors regret this error and indicate that they have uploaded four newly collected replicates to GEO, labeled as a separate batch, and have repeated the relevant analyses and experiments with these new replicates under the same conditions described in the original article. Amended versions of Fig. 3A–C, E, and H, Supplementary Figs. S4B, S4C, and S5H, and Supplementary Table S6 containing the new data from these replicates are included in the Supplementary Data for this notice.
Supplementary Material
updated Supplemental Table S6 with the new data
Footnotes
Note: Supplementary data for this article are available at Cancer Discovery Online (http://cancerdiscovery.aacrjournals.org/).
Reference
- 1. Liu Y, Li Q, Alikarami F, Barrett DR, Mahdavi L, Li H, et al. Small-molecule inhibition of the acyl-lysine reader ENL as a strategy against acute myeloid leukemia. Cancer Discov 2022;12:2684–709. [DOI] [PMC free article] [PubMed] [Google Scholar]
Associated Data
This section collects any data citations, data availability statements, or supplementary materials included in this article.
Supplementary Materials
updated Supplemental Table S6 with the new data