Table 1. Multi-scale MRI parameters (flash 3D sequence: TR = 50 ms, TE = 3.52 ms, FA = 30, FOV 12 × 24 × 16 mm, NA = 1, bandwidth 100 kHz) at 11.7 T. Signal-to-noise (SNR) was calculated by dividing the mean signal intensity by the standard deviation of the noise. Contrast-to-noise (CNR) was defined as the mean signal of the GdAuNP ROI minus the mean signal of tissue prior to division by the standard deviation of the signal in tissue.
| Resolution (μm) | Volume (mm3) | Matrix | Voxels | Time (min) | SNR (original/denoised) | CNR (original/denoised) |
|---|---|---|---|---|---|---|
| 150 | 0.003375 | 80 × 119 × 108 | 1 028 160 | 7 | 47.83/161.66 | 14.52/147.11 |
| 100 | 0.001000 | 120 × 178 × 160 | 3 417 600 | 16 | 29.25/126.06 | 6.26/60.99 |
| 50 | 0.000125 | 240 × 356 × 320 | 27 340 800 | 64 | 10.16/147.61 | 1.53/53.30 |
| 20 | 0.000008 | 600 × 889 × 800 | 426 720 000 | 400 | 3.15/85.01 | 0.36/12.81 |