Table 3.

Univariate and multivariate Cox model analyses of disease-free survival and overall survival

Variables	Disease free survival				Overall survival
	Univariate		Multivariate		Univariate		Multivariate
	HR (95%CI)	p	HR (95%CI)	p	HR (95%CI)	p	HR (95%CI)	p
Age, year (Every 10 years)	1.78 (1.22, 2.44)	<0.001	1.12 (0.71, 1.67)	0.438	2.01 (1.53, 2.68)	<0.001	1.32 (1.02, 2.01)	0.042
Sex (Female vs. Male)	0.88 (0.61, 1.26)	0.482			0.89 (0.59, 1.32)	0.550
Smoking history (Yes vs. No)	0.92 (0.58, 1.32)	0.582			0.96 (0.76, 1.46)	0.682
Hypertension (Yes vs. No)	0.90 (0.44, 1.21)	0.432			0.94 (0.59, 1.38)	0.640
Diabetes mellitus (Yes vs. No)	0.99 (0.63, 1.55)	0.973			1.17 (0.73, 1.86)	0.515
ECOG status (1 vs. 0)	2.15 (1.53, 3.02)	<0.001	1.85 (1.31, 2.67)	0.001	2.86 (1.97, 4.16)	<0.001	2.31 (1.59, 3.48)	<0.001
Surgical method (PN vs. RN)	0.25 (0.14, 0.46)	<0.001	0.72 (0.41, 1.38)	0.301	0.20 (0.10, 0.41)	<0.001	0.52 (0.25, 1.08)	0.067
Side (Right vs. Left)	1.03 (0.74, 1.44)	0.861			1.07 (0.74, 1.55)	0.709
Tumor size, cm (Every 1 cm)	2.01 (1.69, 2.53)	<0.001	1.74 (1.31, 2.07)	<0.001	1.89 (1.53, 2.39)	<0.001	1.68 (1.28, 1.98)	<0.001
pT (Local advanced vs. Localized)	5.43 (3.82, 7.72)	<0.001	3.51 (2.43, 5.21)	<0.001	4.80 (3.26, 7.06)	<0.001	3.08 (2.04, 4.61)	<0.001
Histology type (Non-ccRCC vs. ccRCC)	0.43 (0.19, 0.98)	0.044	0.51 (0.28, 1.16)	0.198	0.35 (0.13, 0.94)	0.037	0.48 (0.22, 1.19)	0.156
Fuhrman grade (High vs. Low)	4.12 (2.72, 6.25)	<0.001	2.82 (1.89, 4.31)	<0.001	2.94 (1.92, 4.48)	<0.001	1.89 (1.28, 2.89)	0.005
PNMLR (>168 vs. <=168)	1.56 (1.11, 2.20)	0.011	1.61 (1.15, 2.29)	0.005	1.75 (1.20, 2.57)	0.004	1.81 (1.24, 2.64)	0.003

Abbreviations: HR Hazard ratio, ECOG Eastern Cooperative Oncology Group, PN Partial nephrectomy, RN Radical nephrectomy, pT pathological stage, ccRCC clear cell renal cell carcinoma