Table 1.
Immunohistochemical differentiation between chRCC, RO, and ccRCC
| chRCC | RO | ccRCC | |
|---|---|---|---|
| C-Kit | + (diffuse) | + (diffuse) | - |
| CK7 | + (> 70%, diffuse) | ± (< 10%, in individual cells) | - |
| EpCAM | + | - | - |
| Hale staining | + | + (luminal) | - |
| Claudin 7 | + (> 70%, membrane) | - (< 10%, in individual cells) | - |
| Vimentin | - | - | + |
| GST-alpha | - | - | + |
| CkAE1/AE3 | + | + | + |
| LMWCK (CAM5.2) | + | + | + |
| Ksp-cadherin | + | + | n/a |
| CAIX | - | - | + |
| Progesterone receptor | + | + | n/a |
ChRCC chromophobe renal cell carcinoma, RO renal oncocytoma, ccRCC clear cell renal cell carcinoma, n/a not available
Source: based on Lüders et al., 2016 and [15]