Table 4.

Four-tier Classification System for chRCC by Avulova et al. with Cancer-Specific Survival (CSS) for 5 and 10 Years According to Liu et al

Grade	Characteristics	5-Year CSS	10-Yeat CSS
1	Wide nuclear spacing, no nuclear crowding or diffuse atypia present, with or without coagulative necrosis	100,0%	98,8%
2	Nuclear crowding with high nucleus/cytoplasm density, as well as contacts between nuclei, and the presence of atypical cells (at least threefold differences in nuclear size with irregular chromatin) without coagulative necrosis	91,4%	91,4%
3	Nuclear crowding (high nucleus/cytoplasm density, as well as contacts between nuclei) and the presence of atypical cells (at least threefold differences in nuclear size with irregular chromatin) with coagulative necrosis	82,1%	82,1%
4	Sarcomatoid dedifferentiation or anaplasia	37,5%	0,0%

CSS Cancer-specific survival