Table 2.
Anthropometric characteristics of infants by different severity of BPD
| Characteristics | Grade 1 (n=19) |
Grade 2 (n=32) |
Grade 3 (n=44) |
P values |
|---|---|---|---|---|
| GA, weeks, mean (ranges) | 27.1(24.0 – 30.0) | 26.3 (23.7-30.4) | 25.5 (23.0-29.6) | 0.001 |
| Birth weight, g, mean (SD) | 1000 (270) | 770 (160) | 710 (250) | <0.0011 |
| Birth weight, z-score, mean (SD) | 0.22 (0.92) | −0.38 (0.84) | −0.40 (1.09) | 0.061 |
| Weight change, birth to 1 week, z-score, mean (SD) | −0.79 (0.39) | −0.43 (0.40) | −0.49 (0.57) | 0.031 |
| Weight at 4-week age, z-score, mean (SD) | −0.60 (0.67) | −0.88 (0.75) | −0.80 (0.73) | 0.42 |
| Weight change over 4 weeks, z-score, mean (SD) | −0.82 (0.42) | −0.50 (0.47) | −0.35 (0.73) | 0.021 |
| Weight at 36 weeks PMA, z-score, mean (SD) | −0.87 (1.07) | −1.40 (1.05) | −1.37 (0.96) | 0.16 |
| Weight at time MRI, z-score, mean (SD) | −0.65 (1.14) | −1.10 (1.17) | −1.29 (1.11) | 0.102 |
| Weight gain by 4 weeks of life, g/kg/day, mean (SD) | 11 (3) | 13 (4) | 14 (5) | 0.041 |
| Regain birth weight, day of life, mean (SD) | 11 (4) | 9 (5) | 9 (6) | 0.29 |
| Nadir weight loss, % from BW, mean (SD) | 10 (5) | 8 (5) | 9 (7) | 0.45 |
| Length at birth, z-score, mean (SD) | 0.28 (0.79) | −0.64 (1.08) | −0.70 (0.93) | 0.0021 |
| Length at 4 weeks age, z-score, mean (SD) | −0.94 (0.80) | −1.57 (0.86) | −1.60 (0.83) | 0.011 |
| Length at 36 weeks PMA, z-score, mean (SD) | −1.42 (1.04) | −2.07 (0.94) | −2.60 (1.12) | <0.001 |
| Length at time of MRI, z-score, mean (SD) | −1.20 (0.92) | −2.28 (1.22) | −2.80 (1.38) | <0.001 |
| Linear growth by 4 weeks of life, cm/week, mean (SD) | 0.6 (0.2) | 0.8 (0.4) | 0.7 (0.3) | 0.40 |
| HC at birth, z-score, mean (SD) | 0.16 (1.12) | −0.68 (0.89) | −0.76 (0.98) | 0.0071 |
| HC at 4 weeks of age, z-score, mean (SD) | −1.09 (0.87) | −1.40 (0.93) | −1.52 (0.85) | 0.21 |
| HC at 36 weeks PMA, z-score, mean (SD) | −1.16 (1.23) | −1.76 (1.03) | −1.69 (0.98) | 0.12 |
| HC at time MRI, z-score, mean (SD) | −1.00 (1.22) | −1.31 (1.06) | −1.64 (1.02) | 0.05 |
GA – gestational age, PMA - postmenstrual age, MRI - magnetic resonance imaging, HC – head circumference
1 -
one-way ANOVA test is significant; post hoc test showed significant difference between mild and moderate, and mild and severe disease but not significant between moderate and severe.
2 -
one-way ANOVA test is marginally significant; post hoc test showed significant difference between mild and severe disease but not significant between mild and moderate, and moderate and severe.