Table 3.
The effect of childhood probiotic intake on the association between prenatal micronutrient supplementation and NDD using the four-way decomposition.
| Component | Crude model | Adjusted model | Full-inclusion model | |||
|---|---|---|---|---|---|---|
| EOR (95%CI) | PA (95%CI), % | EOR (95%CI) | PA (95%CI), % | EOR (95%CI) | PA (95%CI), % | |
| Calcium supplementation | ||||||
| CDE | −0.14 (−0.39, 0.11) | 107 (304, −89) | −0.01 (−0.27, 0.23) | 7 (156, −135) | 0.00 (−0.27, 0.27) | −3 (163, −165) |
| INTref | −0.06 (−0.36, 0.23) | 50 (284, −179) | −0.19 (−0.75, 0.40) | 111 (437, −232) | −0.18 (−0.71, 0.37) | 111 (435, −226) |
| INTmed | −0.03 (−0.15, 0.09) | 20 (115, −73) | −0.04 (−0.16, 0.08) | 23 (91, −48) | −0.02 (−0.07, 0.04) | 10 (41, −22) |
| PIE | 0.10 (0.00, 0.20) | −78 (−1, −157) | 0.07 (−0.03, 0.16) | −40 (19, −96) | 0.03 (−0.02, 0.07) | −18 (11, −45) |
| Total | −0.13 (−0.29, 0.04) | 100 | −0.17 (−0.58, 0.24) | 100 | −0.16 (−0.53, 0.21) | 100 |
| Folic acid supplementation | ||||||
| CDE | −0.05 (−0.38, 0.26) | 30 (218, −150) | 0.09 (−0.23, 0.40) | −23 (58, −99) | 0.14 (−0.21, 0.47) | −42 (63, −144) |
| INTref | −0.19 (−0.54, 0.17) | 109 (309, −100) | −0.52 (−1.22, 0.22) | 129 (302, −54) | −0.47 (−1.17, 0.24) | 144 (359, −73) |
| INTmed | −0.08 (−0.24, 0.08) | 48 (137, −45) | −0.10 (−0.25, 0.05) | 26 (61, −12) | −0.02 (−0.08, 0.03) | 8 (24, −9) |
| PIE | 0.15 (0.00, 0.29) | −86 (−2, −169) | 0.13 (−0.02, 0.26) | −32 (4, −64) | 0.03 (−0.03, 0.09) | −9 (9, −28) |
| Total | −0.17 (−0.37, 0.02) | 100 | −0.40 (−0.89, 0.10) | 100 | −0.33 (−0.79, 0.13) | 100 |
| Iron supplementation | ||||||
| CDE | −0.08 (−0.31, 0.15) | 298 (1,110, −520) | 0.08 (−0.16, 0.33) | 446 (−841, 1,754) | 0.17 (−0.08, 0.42) | 155 (−79, 391) |
| INTref | −0.01 (−0.33, 0.30) | 43 (1,176, −1,068) | −0.09 (−0.66, 0.48) | −478 (−3,486, 2,536) | −0.08 (−0.59, 0.44) | −72 (−551, 407) |
| INTmed | 0.00 (−0.11, 0.10) | 14 (380, −347) | −0.02 (−0.12, 0.09) | −88 (−650, 473) | −0.01 (−0.07, 0.05) | −9 (−66, 48) |
| PIE | 0.07 (0.01, 0.14) | −255 (−22, −494) | 0.04 (−0.03, 0.11) | 220 (−134, 560) | 0.03 (−0.01, 0.07) | 26 (−12, 63) |
| Total | −0.03 (−0.23, 0.17) | 100 | 0.02 (−0.41, 0.45) | 100 | 0.11 (−0.24, 0.45) | 100 |
| Multivitamin supplementation | ||||||
| CDE | −0.22 (−0.46, 0.03) | 65 (137, −9) | −0.03 (−0.28, 0.22) | 10 (85, −66) | −0.04 (−0.30, 0.23) | 11 (95, −74) |
| INTref | −0.16 (−0.49, 0.16) | 48 (148, −49) | −0.30 (−0.91, 0.30) | 92 (273, −92) | −0.28 (−0.81, 0.26) | 89 (261, −83) |
| INTmed | −0.05 (−0.16, 0.05) | 15 (48, −16) | −0.06 (−0.18, 0.06) | 18 (54, −18) | −0.04 (−0.13, 0.04) | 14 (42, −14) |
| PIE | 0.10 (0.03, 0.16) | −29 (−10, −48) | 0.07 (0.00, 0.13) | −20 (1, −40) | 0.05 (−0.01, 0.10) | −15 (2, −32) |
| Total | −0.33 (−0.54, −0.12) | 100 | −0.33 (−0.80, 0.15) | 100 | −0.31 (−0.68, 0.07) | 100 |