TABLE 2.

Linear regression models for WMH volume.

Metabolites	Log DWMH			Log PVWMH			Log TWMH
	β (95% CI)	R2	P	β (95% CI)	R2	P	β (95% CI)	R2	P
Stearidonic acid	−0.565 (−0.895, −0.235)	0.33	0.0017	−0.203 (−0.451, 0.045)	−0.10	0.10	−0.268 (−0.520, −0.016)	0.01	0.038
Adrenic acid	−0.085 (−0.479, 0.308)	−0.04	0.65	−0.020 (−0.272, 0.232)	−0.24	0.86	−0.049 (−0.315, 0.216)	−0.19	0.70
γ-Linolenic acid	−0.370 (−0.743, 0.003)	0.12	0.051	−0.163 (−0.413, 0.087)	−0.15	0.18	−0.209 (−0.468, 0.050)	−0.06	0.10
Linoleic acid	−0.451 (−0.890, −0.012)	0.13	0.044	−0.156 (−0.456, 0.143)	−0.18	0.29	−0.231 (−0.540, 0.077)	−0.08	0.13
Docosahexaenoic acid	−0.575 (−0.937, −0.214)	0.30	0.0032	−0.302 (−0.550, −0.054)	0.03	0.019	−0.363 (−0.614, −0.112)	0.15	0.0066

DWMH, deep white matter hyperintensities; PVWMH, periventricular white matter hyperintensities; TWMH, total white matter hyperintensities.