Table 2.
Association between triglyceride-glucose related indices and cardiometabolic disease incidence among midlife women.
| Unadjusted model | Multivariable model 1† | Multivariable model 2‡ | ||||
|---|---|---|---|---|---|---|
| HR (95% CI) | p value | HR (95% CI) | p value | HR (95% CI) | p value | |
| TyG | ||||||
| Q1 | 1 (Reference) | / | 1 (Reference) | / | 1 (Reference) | / |
| Q2 | 0.95 (0.77–1.17) | 0.61 | 0.98 (0.79–1.22) | 0.87 | 0.93 (0.74–1.16) | 0.51 |
| Q3 | 1.15 (0.94–1.40) | 0.17 | 1.18 (0.96–1.45) | 0.12 | 1.08 (0.87–1.35) | 0.48 |
| Q4 | 1.96 (1.63–2.36) | < 0.01 | 2.03 (1.66–2.47) | < 0.01 | 1.78 (1.41–2.25) | < 0.01 |
| Per 1 SD increase | 1.33 (1.24–1.41) | < 0.01 | 1.32 (1.23–1.41) | < 0.01 | 1.31 (1.20–1.42) | < 0.01 |
| TyG-BMI | ||||||
| Q1 | 1 (Reference) | / | 1 (Reference) | / | 1 (Reference) | / |
| Q2 | 1.52 (1.20–1.92) | < 0.01 | 1.45 (1.14–1.85) | < 0.01 | 1.41 (1.10–1.81) | 0.01 |
| Q3 | 2.32 (1.86–2.89) | < 0.01 | 2.09 (1.66–2.64) | < 0.01 | 1.99 (1.55–2.56) | < 0.01 |
| Q4 | 3.98 (3.23–4.92) | < 0.01 | 3.53 (2.80–4.44) | < 0.01 | 3.26 (2.51–4.24) | < 0.01 |
| Per 1 SD increase | 1.61 (1.52–1.70) | < 0.01 | 1.55 (1.46–1.65) | < 0.01 | 1.52 (1.41–1.63) | < 0.01 |
| TyG-WC | ||||||
| Q1 | 1 (Reference) | / | 1 (Reference) | / | 1 (Reference) | / |
| Q2 | 1.75 (1.39–2.20) | < 0.01 | 1.62 (1.28–2.06) | < 0.01 | 1.57 (1.23–2.00) | < 0.01 |
| Q3 | 2.24 (1.79–2.81) | < 0.01 | 1.88 (1.49–2.38) | < 0.01 | 1.78 (1.38–2.29) | < 0.01 |
| Q4 | 3.95 (3.19–4.88) | < 0.01 | 3.41 (2.72–4.27) | < 0.01 | 3.13 (2.41–4.06) | < 0.01 |
| Per 1 SD increase | 1.60 (1.51–1.70) | < 0.01 | 1.56 (1.46–1.67) | < 0.01 | 1.54 (1.43–1.67) | < 0.01 |
| TyG-WHtR | ||||||
| Q1 | 1 (Reference) | / | 1 (Reference) | / | 1 (Reference) | / |
| Q2 | 1.42 (1.13–1.80) | < 0.01 | 1.34 (1.05–1.70) | < 0.01 | 1.31 (1.02–1.67) | 0.51 |
| Q3 | 2.20 (1.77–2.74) | < 0.01 | 1.80 (1.43–2.27) | < 0.01 | 1.76 (1.37–2.26) | 0.48 |
| Q4 | 3.92 (3.18–4.82) | < 0.01 | 3.33 (2.68–4.15) | < 0.01 | 3.19 (2.47–4.12) | < 0.01 |
| Per 1 SD increase | 1.63 (1.54–1.73) | < 0.01 | 1.58 (1.49–1.69) | < 0.01 | 1.57 (1.46–1.70) | < 0.01 |
†Adjusted for age, race, income, smoking status, and menopause status.
‡Additionally adjusted for low-density lipoprotein, high-density lipoprotein, C-reactive protein, estradiol, and follicle-stimulating hormone.
Abbreviation: HR, hazard ratio; CI, confidence interval, TyG, triglyceride-glucose index, BMI, body mass index, WC, waist circumference. WHtR, waist-to-height ratio.