TABLE 3.
Association of vacA signal sequence type s1 with cagA status and peptic ulcersa
| vacA type |
cagA
|
Past or present peptic ulcers
|
Total | ||
|---|---|---|---|---|---|
| Positive | Negative | Yes | No | ||
| s1 | 31 (21) | 0 (0) | 16 (10) | 15 (11) | 31 (21) |
| s2 | 4 (4) | 2 (1) | 0 (0) | 6 (5) | 6 (5) |
| m1 | 19 (13) | 0 (0) | 7 (5) | 12 (8) | 19 (13) |
| m2 | 16 (12) | 2 (1) | 9 (5) | 9 (8) | 18 (13) |
| Total | 35 (25) | 2 (1) | 16 (10) | 21 (16) | 37 (26) |
a
Shown are the number of H. pylori isolates followed by the number of patients (in parentheses). Note that all H. pylori isolates bearing s1 were cagA positive and that all isolates obtained from patients with peptic ulcers contained s1. No significant relationship was found between vacA midregion type and the presence of cagA or peptic ulcers (P > 0.05, Fisher’s exact test) for isolates or patients.