3. Pharmacokinetic Parameters Calculated from the BVC_S75 Unbound Concentration–Time Profiles inside the Tumor Tissue.

Parameters	free BVC	NLC-L-BVC	NLC-BVC
ke (h–1)	0.91 ± 0.19	0.16 ± 0.08	0.18 ± 0.10
t1/2 (h)	0.80 ± 0.17	5.8 ± 3.60	4.9 ± 2.70
AUC0‑∞ (μg·h/mL)	178 ± 96	2005 ± 712	1243 ± 230
C0 (μg/mL)	509.1 ± 315.2	464.8 ± 127.7	463.3 ± 159.1

^a p < 0.0001 in comparison to free BVC_S75.

^b p < 0.05.

^c p < 0.01.