Table 3.
Results of stability studies of CUR+CYC-etho-gel.
| Stability parameter | Results (day 0) |
Results (after 3 months) |
||
|---|---|---|---|---|
| 4 °C ± 3 °C | 25 °C ± 2 °C/ 60% RH ± 5% RH | 40 °C ± 2 °C/ 75% RH ± 5% RH | ||
| Physical appearance | Yellow colored clear and transparent gel with no grittiness | Same as day 0 | Same as day 0 | Same as day 0 |
| pH | 6.22 ± 0.11 | 6.32 ± 0.32 | 6.28 ± 0.64 | 6.16 ± 0.24 |
| Particle size (nm) | 93.31 ± 1.17 | 90.53 ± 1.31 | 91.39 ± 1.26 | 91.74 ± 1.49 |
| Zeta potential (mV) | −29.2 ± 0.17 | −29.2 ± 0.23 | −28.4 ± 0.35 | −26.7 ± 0.28 |
| Viscosity (cPs) | 6781 ± 1.20 | 6752 ± 1.52 | 6782 ± 1.63 | 6634 ± 1.28 |
| Spreadablility (g cm/s) | 18 ± 1.25 | 18 ± 1.83 | 18 ± 1.37 | 18 ± 1.81 |
| Assay | ||||
| 1) CUR | 98.52 ± 0.31% | 98.38 ± 0.41% | 99.14 ± 1.73% | 100.01 ± 1.25% |
| 2) CYC | 97.16 ± 0.61% | 97.22 ± 0.62% | 98.73 ± 0.44% | 99.18 ± 1.82 % |
All measurements were carried out in triplicates (n = 3). Data are presented as mean ± standard Deviation (SD).
Abbreviations: CUR – Curcumin, CYC – Cyclosporine, PDI – Polydispersity Index, nm – nanometer, mV – millivolt, RH -Relative Humidity, cPs – centipoise, g.cm/s – Gram Centimeter Per Second.