TABLE 3.

Shifts in antifungal activity between planktonic and biofilm forms of Candida^a

Specie	Drug	Comparison	P value		Comparison	P value
C. albicans	CAS	MIC vs MBC	0.0238	*
C. auris	RZF	MIC vs MBC	<0.0001	****	MBC vs MBEC	0.0003	***
		MIC vs MBEC	0.0084	**	MBC vs MBDC	<0.0001	****
	MNGX	MIC vs MBC	0.0034	**
		MIC vs MBEC	0.0166	*
	CAS	MIC vs MBC	<0.0001	****	MBC vs MBDC	<0.0001	****
		MIC vs MBEC	<0.0001	****	MBEC vs MBDC	0.013	*
C. parapsilosis	RZF	MIC vs MBC	<0.0001	****	MBC vs MBDC	0.0048	**
		MIC vs MBEC	<0.0001	****	MBEC vs MBDC	0.0403	*
		MIC vs MBDC	0.0306	*
	CAS	MIC vs MBC	0.0007	***	MBC vs MBEC	0.0167	*
		MIC vs MBEC	<0.0001	****	MBEC vs MBDC	<0.0001	****

^a Two-way analysis of variance (ANOVA) and post-hoc comparisons with Dunnett’s multiple comparison tests [P < 0.03 (*); P < 0.0021 (**); P < 0.0002 (***); P < 0.0001 (****)]. Observed statistical differences among MIC, MBC, MBEC, and MBDC are attributed to greater shifts in antifungal activity displayed by certain antifungals when transitioning from planktonic cells to biofilms.