TABLE 3.
Immunoreactivities of five anti-37-kDa MAbs to drug-resistant isolates of pneumococci and MICs for clinical isolatesa
| Isolate | Sero- type | MIC (μg/ml) ofb:
|
Reactivity of all 5 MAbs | ||||||
|---|---|---|---|---|---|---|---|---|---|
| PEN | CTX | SXT | TET | ERY | CLIN | CHL | |||
| MD-9095 | 19A | 0.12 | 0.06 | 0.12 | ≤0.5 | 8–32 | 0.5 | 2 | + |
| TS-80 | 9V | 4 | 4 | 4 | ≤0.5 | >32 | 0.5 | 2 | + |
| TS-148 | 6A | 1.0 | 0.5 | 4 | >16 | >32 | >32 | 4 | + |
| TX-282 | 6A | 2 | 1.0 | 8 | >16 | >32 | >32 | 4 | + |
| 97-018867 | 23F | 1.0 | 1.0 | 1.0 | 32 | >8 | >8 | 8 | + |
a
MICs were measured according to guidelines of the NCCLS, and breakpoint criteria used to define strains were based on the NCCLS MIC interpretive standards (31).
b
PEN, penicillin; ERY, erythromycin; CTX, cefotaxime; SXT, sulfamethoxazole-trimethoprim; CLIN, clindamycin; TET, tetracycline; CHL, chloramphenicol.