Table 3.
Univariate and multivariate Cox regression for analyzing the overall survival for patients with primary Gastrointestinal DLBCL.
| Variables | Univariate | Multivariate | ||||
|---|---|---|---|---|---|---|
| HR | 95% CI | P-value | HR | 95% CI | P-value | |
| Age, years | ||||||
| ≤ 68 | 1 | Reference | 1 | Reference | ||
| 69–80 | 2.39 | 2.25, 2.53 | < 0.001 | 2.39 | 2.25, 2.54 | < 0.001 |
| ≥ 81 | 4.67 | 4.39, 4.98 | < 0.001 | 4.07 | 3.81, 4.35 | < 0.001 |
| Sex | ||||||
| Male | 1 | Reference | 1 | Reference | ||
| Female | 1.05 | 1.00, 1.11 | 0.045 | 0.83 | 0.79, 0.87 | < 0.001 |
| Race | ||||||
| White | 1 | Reference | 1 | Reference | ||
| Black | 1.04 | 0.95, 1.15 | 0.389 | 1.29 | 1.17, 1.42 | < 0.001 |
| Others | 0.84 | 0.77, 0.90 | < 0.001 | 0.93 | 0.86, 1.01 | 0.097 |
| Marital status | ||||||
| Married | 1 | Reference | 1 | Reference | ||
| Unmarried | 1.37 | 1.30, 1.44 | < 0.001 | 1.26 | 1.20, 1.33 | < 0.001 |
| Stage | ||||||
| Stage I | 1 | Reference | 1 | Reference | ||
| Stage II | 1.09 | 1.03, 1.95 | < 0.001 | 1.31 | 1.22, 1.40 | < 0.001 |
| Stage III | 1.24 | 1.07, 2.02 | < 0.001 | 1.33 | 1.19, 1.44 | < 0.001 |
| Stage IV | 2.02 | 1.91, 2.15 | < 0.001 | 2.66 | 2.50, 2.83 | < 0.001 |
| Location | ||||||
| Stomach | 1 | Reference | 1 | Reference | ||
| Small intestine | 0.82 | 0.77, 0.87 | < 0.001 | 0.91 | 0.88, 0.98 | 0.021 |
| Colorectum | 0.86 | 0.80, 0.91 | < 0.001 | 0.89 | 0.82, 0.95 | < 0.001 |
| Treatment method | ||||||
| No therapy | 1 | Reference | 1 | Reference | ||
| Surgery only | 0.66 | 0.61, 0.71 | < 0.001 | 0.72 | 0.66, 0.78 | < 0.001 |
| Chemotherapy only | 0.36 | 0.34, 0.38 | < 0.001 | 0.37 | 0.34, 0.40 | < 0.001 |
| Radiation only | 0.81 | 0.67, 0.97 | 0.023 | 0.71 | 0.59, 0.85 | < 0.001 |
| Chemotherapy + Radiation | 0.27 | 0.24, 0.30 | < 0.001 | 0.35 | 0.31, 0.39 | < 0.001 |
| Surgery + Chemotherapy | 0.26 | 0.24, 0.28 | < 0.001 | 0.31 | 0.28, 0.34 | < 0.001 |
| Surgery + Radiation | 0.68 | 0.44, 1.04 | 0.076 | 0.49 | 0.32, 0.75 | 0.001 |
| Surgery + Chemotherapy + Radiation | 0.28 | 0.22, 0.36 | < 0.001 | 0.38 | 0.30, 0.48 | < 0.001 |
DLBCL: diffuse large B-cell lymphoma; HR: hazard ratios; CI: confidence interval; Others: American Indian, Alaska Native, Asian/Pacifc Islander; bold values indicate P < 0.05.