Table 2.
Anti-RSV drugs inhibiting propagation.
| Name | Category | Target | Structure | Development |
|---|---|---|---|---|
| EDP938 | Small-molecule | RSV N |  |
Phase 2 |
| RSV604 | Small-molecule | RSV N |  |
Preclinical |
| ALS-8176 | Small-molecule | RSV L |  |
Phase 2 |
| Remdesivir | Small-molecule | RSV L |  |
Phase 2 |
| PC786 | Small-molecule | RSV L |  |
Phase 2 |
| AZ-27 | Small-molecule | RSV L |  |
Preclinical |
| JNJ-8003 | Small-molecule | RSV L |  |
Preclinical |
| DZ7487 | Small-molecule | RSV L | Unpublished | Preclinical |
| Ribavirin | Small-molecule | RSV L |  |
Accepted in 1986 |
| Molnupiravir | Small-molecule | RSV L |  |
Phase 2 |
| 4′-Fluorouridine | Small-molecule | RSV L |  |
Preclinical |
| ALN-RSV01 | siRNA | RSV N mRNA | RNA, (CUU GAC UUU GCU AAG AGC CdTdT), complex with RNA (GGC UCU UAG CAA AGU CAA GdTdT) | Phase 2 |
| DZn1133 | Dzs | RSV N mRNA | 5′-TGG GGC AAA GGC TAG CTA CAA CGA ACA AAG ATG-3′ | Preclinical |
| DZ604 | Dzs | RSV NS2 RNA | 5′-ATG GGG CAA AGG CTA GCT ACA ACG AAA ATC AAT TCA-3′ | Preclinical |
| Verdinexor | Small-molecule | RSV M |  |
Phase 1 |