Table 5.

Studies of dual triggering in patients with high ovarian response.

Retrospective cohort studies
Author/Design	N	Patients	Groups	No. of oocytes retrieved	N° MII	Fertilization rate	Total embryos	Good quality embryos	Transferred embryos	OHSS	Pregnancy BhCG+	LBR
Li S et al 2018 (67)	226	High response	G1 control: 10000IU hCG G2: 0.2mg GnRH + 2000IU hCG G3: 8000IU hCG	G1: 18.54 ± 4.38 G2: 21.63 ± 7.43 G3: 20.27 ± 5.42 G1 vs. G3: p = 0.002 p= 0.034	NI	G1: 68.82 ± 19.49 G2: 64.86 ± 18.67 G3: 70.81 ± 17.10 p=NS	G1: 10.19 ± 4.61 G2: 13.58 ± 7.21 G3: 12.25 ± 5.28 G1 vs G3: p= 0.001 G1 vs G2: p= 0.011	G1: 52.83 ± 23.71 G2: 64.21 ± 22.34 G3: 59.60 ± 19.37 G1 vs G3: p= 0.005 G1 vs G2: p= 0.038	NI	G1: 56 (57.14%) G2: 17 (39.53%) G3: 37 (43.53%) In G3: 5 severe OHSS patients	NI	NI
Oliveira SA et al 2016 (64)	24	High response	G1: 0.2mg GnRHa + 2500IU hCG G2: 0.2mg GnRHa	G1:7.03± 3.12 G2: 4.67 ± 1.63 p=NS	G1:5.38 ± 3.82 G2:3.32 ± 1.24 p=NS	NI	G1: 4.02 ± 2.34 G2: 2.80 ± 1.43 p=NS	G1:2.12 ± 1.68 G2:1.93 ± 1.45 p=NS	G1: 1.45 ± 0.82 G2: 1.53 ± 0.93 p=NS	NI	G1: 50.00% G2: 27.27% p=NS	G1: 44.4% G2: 16.13% p=NS per embryo transfer
O’Neill KE et al., 2016 (65)	177	High response	G1: 4mg GnRHa G2: 4mg GnRHa + 1000 IU hCG.	G1: 16.5 (11-21.5) 3 patients puncture without oocytes. G2: 17.5 (12–24)	G1: 70 (56–85) G2: 82 (74–91) p< 0.01	NI	NI	NI	G1: 45% G2: 88% p <0.01	G1: 0 G2:6 p <0.01	G1: 63% G2: 44% p= 0.12	NI
Griffin D et al., 2012 (66)	102	High response	G1: 1mg GnRHa G2: 1000 IU hCG + 1mg GnRHa	G1: 24 ± 10 G2: 23 ± 10 p=NS	NI	G1:81.9 ± 18.1 G2: 79.2 ± 13.9 p= NS	G1: 4.3 ± 4.7 G2: 3.6 ± 3.1 p= 0.03	NI	G1: 1.8 ± 0.4 G2: 1.8 ± 0.5 p= NS	NI	G1: 36.8% G2: 58.8% p= 0.03	G1: 30.9% G2: 52.9% p=0.03

NI, no information; NS, no statistically significant differences; OHSS, ovarian hyperstimulation syndrome; MII, metaphase II oocytes; LBR, Live birth rate; G1, Group 1; G2, Group 2.