Table 2.

COX regression analysis of risk factors for DM in training cohort.

Factor	Category	Univariate analysis			Multivariate analysis
		HR	95%CI	P	HR	95%CI	P
Age (years)		1.02	1.01–1.03	0.01*	1.01	0.99–1.02	0.08
Sex	Female	1.00			–
	Male	1.04	0.99–1.09	0.16	–
AFP Custom (ng/mL)	AFP-	1.00			1.00
	AFP+	2.36	1.37–4.05	<0.001*	1.80	1.03–3.14	0.04*
T Stage	T1	1.00			1.00
	T2	1.32	0.56–3.08	0.53	1.01	0.43–2.38	0.98
	T3	3.82	2.11–6.91	<0.01*	2.55	1.38–4.74	<0.001*
	T4	6.91	3.92–12.19	<0.01*	3.31	1.79–6.12	<0.01*
N Stage	N0	1.00			1.00
	N1	1.58	0.94–2.64	0.08	1.21	0.71–2.05	0.48
	N2	3.17	2.12–4.73	<0.01*	1.91	1.24–2.93	<0.001*
	N3	5.35	3.72–7.69	<0.01*	2.35	1.49–3.71	<0.01*
M Stage	M0	1.00			–
	M1	3.50	2.10–5.85	<0.01*	1.85	1.08–3.16	0.03*
Histology	AD	1.00			–
	MAD	0.95	0.85–1.05	0.37	–
	SRCC	0.95	0.71–1.26	0.72	–
	Other	0.88	0.73–1.03	0.13	–
Liver Metastases	Absent	1.00			–
	Present	2.45	1.42–4.22	<0.001*	–
Tumor Size (cm)		1.15	1.08–1.22	<0.01*	1.07	0.99–1.15	0.08
CA19-9 (U/mL)		1.01	1.01–1.01	<0.01*	–
CEA (ng/mL)		1.01	1.01–1.01	0.04*	–
Number of lymph node		0.99	0.98–1.01	0.29	–
Lymph node (mm)		1.05	1.04–1.06	<0.01*	1.02	1.01–1.04	0.01*

Multivariable HR adjusted for T/N/M-stage, tumor size. *P<0.05.