Figure 2.

System diagram of the AI-W algorithm. The AI-F method was integrated as a building block to analyze all image FOVs in the WSI. The processing of FOVs with both high and low expressions of sTILs was exemplified, with intermediate cell-level and region-level results demonstrated in a pipeline. All of the mononuclear inflammatory cell (MIC)-occupied pixels in the WSI constituted the numerator of sTILs, while the total number of tumor-associated stroma pixels was the denominator. AI-F, artificial intelligence-field of view; AI-W, artificial intelligence; FOVs, fields of view; sTILs, stromal tumor-infiltrating lymphocytes; WSI, whole-slide image.