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. 2025 Jun 4;105(1):e213781. doi: 10.1212/WNL.0000000000213781

Table 3.

Observed Means (SD) or Median [IQR] of the Secondary Outcomes at the Different Measurement Occasions

Baseline After intervention 6-mo follow-up 12-mo follow-up
N Mean (SD) or median [IQR] N Mean (SD) or median [IQR] N Mean (SD) or median [IQR] N Mean (SD) or median [IQR]
Steps (daily)
 Intervention 36 4,287 [2,317–5,114] 27 4,877 [3,159–6,970] 30 4,875 [3,868–5,789] 32 4,991 [3,281–5,904]
 Control 41 4,634 [3,357–6,697] 32 4,172 [2,646–5,871] 29 4,729 [2,572–5,996] 28 4,673 [2,570–6,685]
Time spent in MVPA (min/daily)
 Intervention 28 91 [20–152] 21 93 [44–112] 26 72 [42–163] 22 117 [67–190]
 Control 35 112 [64–188] 25 86 [54–167] 22 106 [62–186] 25 107 [77–159]
SF-36: physical component score (0–100)
 Intervention 44 41.4 (8.5) 40 42.3 (9.5) 37 41.6 (9.8) 37 41.3 (9.5)
 Control 46 38.0 (10.4) 42 38.4 (11.4) 42 37.3 (11.1) 38 38.0 (11.5)
SF-36: mental component score (0–100)
 Intervention 44 54 (3.4) 40 53.9 (3.7) 37 54.6 (3.5) 37 54.2 (3.1)
 Control 46 54.8 (3.9) 42 54.2 (5.1) 42 55.2 (4.4) 38 55.0 (4.4)
ACTIVLIM (−6.6 to 6.3)
 Intervention 44 2.4 (1.7–3.6) 40 2.6 (1.7–3.5) 37 2.7 (2.1–3.5) 37 2.5 (1.6–3.5)
 Control 46 2.1 (1.5–3.1) 42 1.9 (1.4–3.1) 42 2.1 (1.4–2.7) 38 2.1 (1.2–2.9)
Self-efficacy scale (0–25)
 Intervention 44 19.2 (3.1) 40 17.2 (3.7) 37 17.5 (3.6) 37 17.0 (3.7)
 Control 46 18.3 (3.7) 42 16.4 (3.7) 42 16.6 (3.0) 38 15.6 (4.5)
MVT musculus quadriceps strongest leg (Nm)
 Intervention 44 106.5 (44.5) 37 107.9 (38.4) 30 114.9 (41.3) 33 113.0 (43.7)
 Control 44 98.0 (41.8) 36 96.3 (46.0) 35 98.1 (45.5) 29 97.4 (45.4)
MVT musculus triceps surae strongest leg (Nm)
 Intervention 33 42.7 (26.0) 26 43.7 (24.1) 20 49.7 (27.8) 23 43.2 (24.7)
 Control 44 39.3 (18.9) 34 37.5 (19.3) 31 42.5 (23.2) 25 40.2 (21.4)
Cholesterol (mmol/L)
 Intervention 44 5.55 (0.97) 37 5.44 (1.01) 32 5.44 (1.18) 33 5.34 (0.97)
 Control 46 5.36 (0.94) 38 5.52 (1.17) 34 5.37 (1.12) 33 5.26 (1.07)
HDL (mmol/L)
 Intervention 44 1.67 (0.39) 37 1.70 (0.44) 32 1.77 (0.39)0 33 1.70 (0.37)
 Control 46 1.64 (0.43) 38 1.72 (0.46) 34 1.74 (0.42) 33 1.67 (0.46)
LDL (mmol/L)
 Intervention 44 3.41 (0.86) 37 3.29 (0.93) 32 3.20 (1.17) 33 3.15 (0.86)
 Control 46 3.27 (0.79) 38 3.40 (0.97) 34 3.23 (0.87) 33 3.16 (0.90)
VLDL (mmol/L)
 Intervention 44 3.50 (1.00) 37 3.39 (1.11) 32 3.24 (1.11) 33 3.28 (0.92)
 Control 46 3.43 (0.90) 38 3.33 (1.06) 34 3.19 (0.73) 33 3.32 (0.98)
Triglycerides (mmol/L)
 Intervention 44 1.04 (0.61) 37 1.01 (0.57) 32 0.99 (0.57) 33 1.08 (0.80)
 Control 46 1.02 (0.54) 38 0.99 (0.55) 34 0.90 (0.39) 33 0.97 (0.52)
Glucose (mmol/L)
 Intervention 44 5.4 (0.7) 37 5.3 (0.6) 32 5.4 (0.6) 33 5.2 (0.6)
 Control 46 5.4 (0.5) 38 5.5 (0.6) 34 5.4 (0.5) 33 5.6 (0.6)
Waist circumference (cm)
 Intervention 32 94.6 (10.3) 32 94.3 (12.8) 28 93.7 (11.5) 31 95.6 (12.0)
 Control 33 96.1 (12.1) 31 92.6 (9.3) 34 93.9 (9.2) 30 93.2 (8.0)
Creatine kinase (U/L)
 Intervention 44 196 (165) 37 245 (234) 32 211 (176) 33 217 (176)
 Control 46 199 (451) 38 195 (450) 34 227 (600) 33 286 (958)
Blood pressure: diastolic (mm Hg)
 Intervention 44 126 (13) 35 122 (18) 32 119 (16) 33 120 (18)
 Control 47 133 (17) 39 125 (14) 32 125 (15) 29 123 (13)
Blood pressure: systolic (mm Hg)
 Intervention 44 76 (10) 35 75 (12) 32 72 (11) 33 75 (10)
 Control 47 78 (8) 39 75 (9) 32 71 (10) 29 74 (10)
WECT: distance (m)
 Intervention 42 371.4 (74.3) 37 385.6 (74.3) 32 400.3 (80.3) 33 391.9 (89.8)
 Control 45 360.7 (99.0) 39 366.7 (100.5) 36 372.4 (103.3) 33 367.6 (110.0)
WECT: steady state (VO2 in mL/min/kg)
 Intervention 40 14.7 (2.8) 26 16.0 (2.3) 28 15.6 (2.4) 26 16.5 (3.1)
 Control 42 14.0 (2.9) 36 14.4 (2.9) 33 14.7 (3.1) 28 15.0 (3.8)

Abbreviations: HDL = high-density lipoprotein; IQR = interquartile range; LDL = low-density lipoprotein; MVPA = moderate-to-vigorous physical activity; MVT = maximal voluntary torque; SF-36 = Short Form 36-Item; VLDL = very low–density lipoprotein; VO2 = oxygen consumption; WECT = walking energy consumption test.

Steps, time spent in MVPA, and ACTIVLIM are shown as median [interquartile range]. All other variables are shown as mean (SD).