Skip to main content
. 2025 Jun 4;105(1):e213781. doi: 10.1212/WNL.0000000000213781

Table 4.

Intervention Effects of the Secondary Outcomes at the Different Measurement Occasions

Over time After intervention 6-mo follow-up 12-mo follow-up
Mean (95% CI) p Value Mean (95% CI) p Value Mean (95% CI) p Value Mean (95% CI) p Value
Steps 242 (−585 to 1,069) 0.564 729 (−330 to 1,789) 0.176 −429 (−1,528 to 670) 0.442 339 (−737 to 1,416) 0.534
Time spent in MVPA −1.4 (−38.6 to 35.8) 0.940 11.3 (−44.6 to 67.2) 0.689 −11.3 (−66.2 to 43.6) 0.684 7.6 (−49.7 to 65.0) 0.792
SF-36: physical component score 1.1 (−1.7 to 3.8) 0.439 0.7 (−2.7 to 4.1) 0.702 1.5 (−1.9 to 5.0) 0.379 1.0 (−2.5 to 4.5) 0.586
SF-36: mental component score 0.1 (−1.1 to 1.2) 0.910 0.4 (−1.1 to 1.9) 0.586 0.0 (−1.6 to 1.5) 0.969 −0.2 (−1.7 to 1.4) 0.818
ACTIVLIM 0.1 (−0.3 to 0.5) 0.506 0.0 (−0.4 to 0.4) 0.950 0.3 (−0.1 to 0.7) 0.176 0.1 (−0.3 to 0.5) 0.639
Self-efficacy scale 0.5 (−0.8 to 1.7) 0.454 0.3 (−1.2 to 1.9) 0.670 0.4 (−1.2 to 1.9) 0.616 0.7 (−0.8 to 2.3) 0.357
MVT musculus quadriceps strongest leg −0.3 (−6.6 to 6.1) 0.932 −1.4 (−9.2 to 6.4) 0.724 1.1 (−7.1 to 9.3) 0.792 0.1 (−8.2 to 8.4) 0.988
MVT musculus triceps surae strongest leg −0.8 (−5.9 to 4.3) 0.760 −0.9 (−7.6 to 5.8) 0.784 0.9 (−6.3 to 8.2) 0.797 −1.9 (−9.3 to 5.4) 0.602
Cholesterol −0.1 (−0.4 to 0.2) 0.502 −0.2 (−0.5 to 0.2) 0.265 0.0 (−0.3 to 0.4) 0.880 −0.1 (−0.5 to 0.3) 0.558
HDL 0.0 (−0.1 to 0.0) 0.321 0.0 (−0.1 to 0.1) 0.843 0.0 (−0.1 to 0.1) 0.510 −0.1 (−0.2 to 0.0) 0.085
LDL −0.1 (−0.4 to 0.1) 0.298 −0.2 (−0.6 to 0.1) 0.139 −0.1 (−0.4 to 0.3) 0.728 −0.1 (−0.4 to 0.2) 0.545
VLDL 0.0 (−0.2 to 0.2) 0.873 0.0 (−0.3 to 0.2) 0.777 0.1 (−0.2 to 0.4) 0.451 0.0 (−0.3 to 0.3) 0.991
Triglycerides 0.1 (0.0 to 0.3) 0.094 0.1 (−0.1 to 0.2) 0.559 0.2 (0.0 to 0.4) 0.049 0.1 (0.0 to 0.3) 0.152
Glucose −0.1 (−0.2 to 0.0) 0.186 0.0 (−0.2 to 0.1) 0.576 0.0 (−0.2 to 0.2) 0.752 −0.2 (−0.4 to −0.1) 0.008
Waist circumference 1.3 (−1.0 to 3.6) 0.258 2.4 (0.1 to 4.7) 0.042 1.5 (−0.7 to 3.8) 0.177 1.3 (−1.0 to 3.6) 0.258
Creatine kinase −0.7 (−52.0 to 50.6) 0.978 46.3 (−39.0 to 131.5) 0.286 −5.6 (−95.8 to 84.5) 0.902 −49.4 (−140.3 to 41.5) 0.285
Blood pressure: diastolic 1.0 (−2.5 to 4.4) 0.571 1.3 (−2.8 to 5.5) 0.521 0.8 (−3.6 to 5.1) 0.725 0.6 (−3.8 to 5.0) 0.774
Blood pressure: systolic −0.6 (−5.6 to 4.4) 0.814 0.4 (−5.9 to 6.8) 0.892 −2.7 (−9.5 to 4.0) 0.425 0.7 (−6.2 to 7.5) 0.848
WECT: distance 5.1 (−7.3 to 17.5) 0.411 1.5 (−12.9 to 15.8) 0.840 10.8 (−4.1 to 25.8) 0.153 3.9 (−11.2 to 19.0) 0.611
WECT: steady state 0.9 (0.0 to 1.8) 0.041 1.1 (−0.0 to 2.2) 0.053 0.8 (−0.3 to 1.9) 0.173 0.9 (−0.3 to 2.0) 0.145

Abbreviations: HDL = high-density lipoprotein; LDL = low-density lipoprotein; MVPA = moderate-to-vigorous physical activity; MVT = maximal voluntary torque; SF-36 = Short Form 36-Item; VLDL = very low–density lipoprotein; WECT = walking energy consumption test.