Table 1.
Demographic and clinical variables. Chi-square was used for categorical and independent T-tests, and the Mann-Whitney test was used for scale variables. Statistical significance is defined as having a p-value less than 0.05.
| Characteristic | CLDN high (n = 58) | CLDN Low (n = 14) | P-value |
|---|---|---|---|
| Age at diagnosis, mean year (SD) | 54.3(11.6) | 58.6(12.7) | 0.223 |
| Tumor grade, N (%) | |||
| Grade 1 | 2 (3.4) | 2 (14.3) | 0.281 |
| Grade 2 | 15 (25.9) | 3 (21.4) | |
| Grade 3 | 41 (70.7) | 9 (64.3) | |
| Disease Stage, N (%) | 0.154 | ||
| 1 | 16 (24.6) | 6 (42.9) | |
| 2 | 25 (43.1) | 4 (28.6) | |
| 3 | 13 (22.4) | 1 (7.1) | |
| 4 | 4 (6.9) | 3 (21.4) | |
| Type of surgery received, N (%) | |||
| Lumpectomy | 39 (67.2) | 10 (71.4) | 0.517 |
| Mastectomy | 19 (32.8) | 4 (28.6) | |
| No surgery | 0 () | 0 () | |
| lymph node involvement, N (%) | 18 (31.0) | 4 (28.6) | 0.567 |
| Tumor size (cm), N (%) | |||
| ≤ 2 | 16 (27.6) | 6 (42.9) | 0.368 |
| >2 | 42 (72.4) | 8 (57.0) | |
| Cancer history in the family, N (%) | |||
| No | 30 (51.7) | 6 (42.9) | 0.587 |
| Breast Cancer | 15 (25.9) | 3 (21.4) | |
| Other cancers | 13 (22.4) | 5 (35.7) | |
| Treatment type | 0.560 | ||
| Chemotherapy and radiotherapy | 51 (87.9) | 12 (85.7) | |
| Chemotherapy | 7 (12.1) | 2 (14.3) | |
| Ki-67 expression, mean % (±SD) | 46.55(±20.2) | 42.79(±20.2) | 0.617 |
| Disease history, N (%) | |||
| No history | 37 (63.8) | 11 (78.0) | 0.234 |
| CVD, hypertension, or diabetes | 21 (34.5) | 3 (21.4) |