TABLE 1.
Specificity of HDV editing in transfected Huh-7 cells
| RNA (no. of clones analyzed) | No. (%) with:
|
A→G changes at amber/W as % of all A→G changesa | Non-amber/W A→G changes/RNA | ||
|---|---|---|---|---|---|
| Modifications at amber/W | Non-amber/W A→G changes | Non-A→G changes | |||
| Replicating (84) | 24 (29) | 3 (0.05b) | 9 (0.03)c | 89 | 0.16 |
| Nonreplicating (97) | 35 (36) | 7 (0.09) | 1 (.003) | 83 | 0.32 |
a
(No. of clones edited at the amber/W site)/(total no. of A→G changes)] × 100.
b
% = [(no. of changes)/(no. of adenosines × no. of clones)] × 100.
c
For replicating RNA, includes four U→C changes.