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. Author manuscript; available in PMC: 2025 Jun 6.
Published in final edited form as: Sci Transl Med. 2025 Jan 29;17(783):eadq1086. doi: 10.1126/scitranslmed.adq1086

Fig. 8. Transcriptomic sex differences in innate immune cells are present between primary and breakthrough infections.

Fig. 8.

(A and B) Heatmaps of enriched BTMs in innate immune subsets as described in Fig. 1F in female (A) and male (B) infected UVI (n = 19) versus VI (n = 17) participants from the scRNA-seq dataset with the top 20 BTMs displayed. (C and D) Box plots depicting the arcsinh-transformed MSI of protein expression in NK cells from UVI (C) and VI (D) participants under unstimulated conditions from the mass cytometry dataset (n = 19 UVI participants and n = 17 VI participants). (E and F) Box plots depicting the normalized protein expression of plasma proteins in UVI (n = 30) (E) and VI (n = 24) (F) participants from the Olink dataset. *P ≤ 0.05 and **P ≤ 0.01 by t test with Benjamini-Hochberg’s correction for multiple hypothesis testing. ITK, IL2 inducible T cell kinase; RA, retinoic acid; PKC, protein kinase C; CSF, colony-stimulating factor.