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. 2025 Jun 6;16:5260. doi: 10.1038/s41467-025-60334-y

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© The Author(s) 2025

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 5 — A Schematic representation of the single-cell RNA-seq approach to investigate the cellular and transcriptional landscape in basal condition (control-uninjured, N = 2) and during regeneration after partial ablation (0,1,9 dppa) and partial hepatectomy (4, 11 dpi). B UMAP visualization of cell types detected in zebrafish larval liver, combining data from injured and uninjured liver conditions. C Heatmap displaying the average scaled expression of selected markers across different cell types. D UMAP visualization focusing on specific injured conditions, highlighting mTagBFP2+ cells and spared hepatocytes (0,1,9 dppa and 4,11 dpi), control hepatocytes, control cholangiocytes, and cholangiocytes in injured conditions (cholangiocytes-rest). The remaining clusters are shown in gray. E Correlation matrix of hierarchically clustered mTagBFP2+ and spared hepatocytes compared to control hepatocytes and cholangiocytes. F Heatmap showing the normalized expression of hepatocyte and cholangiocyte-specific marker genes. Expression of selected genes that are detected in mTagBFP2+ cells at 0 dppa, 1 dppa and 4 dpi are outlined (dashed rectangles).