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. 2025 Jun 6;16:5260. doi: 10.1038/s41467-025-60334-y

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© The Author(s) 2025

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 6 — A The transgenic lines used to lineage trace her2+ cells. B Schematic illustrating the tracing of her2 + -derived hepatocytes following PHx. C Experimental timeline for lineage tracing. D, F Live confocal images of left lobe in uninjured and PHx condition at 4 dpi (D) and at 8 dpi (F). Representative cholangiocyte-derived de novo hepatocytes are marked with arrowheads. Dashed line marks the border of the regenerate. E, G Min-to-max box plots showing the normalized number of H2B-mGL⁺/mCherry⁺ hepatocytes per unit volume at 4 dpi (E) and 8 dpi (G). Each dot represents one animal; mean ± SEM is indicated above each box. Statistical significance was assessed using the Two-tailed Mann–Whitney test. Sample sizes are indicated below the respective groups. Scale bars: 100 μm (left panels), 50 μm (insets) (D, F).