TABLE 1.
Sequences and Stat binding properties of the C/EBPδ APRE and several known SBEs
| Gene | SBEa | Binding to:
|
Reference(s) | |
|---|---|---|---|---|
| Stat1 | Stat3 | |||
| Murine C/EBPδ | TCG TT CCC AGCA GCA | − | + | This study |
| Rat C/EBPβ | TGT TT CCC AGAA GTT | + | + | This study |
| Rat α2-m | GAA TT CCC AGAA GGA | + | + | 17, 27 |
| Human hemopexin | TTT TT CCC GGCA GGA | ND | ND | 22 |
| Rat α1-acid glycoprotein | TTT TT CCC AGAA GCC | ND | ND | 49 |
| Human haptoglobin | CTT TT CCA GTAA CAA | ND | ND | 32 |
| Human γ-fibrinogen | TTC TT CCA GTAC ATG | ND | + | 51 |
| Human α1-antichymotrypsin | CTA TT ACA GAAA ATT | ND | ND | 4 |
| Human C-reactive protein | CTC TT CCC GAAG CTC | ND | + | 50 |
| Human LBP | AGA TT CCC AGTG CAG | ND | + | 41 |
| Murine junB | CGC TT CCT GACA GTG | − | + | 12 |
| Human c-fos | CAG TT CCC GTCA ATC | + | + | 8 |
| Human ICAM-1 | GCT TT CCC GGAA ACC | + | + | 7, 28 |
a
SBEs from a number of cytokine-inducible genes are shown in alignment with the C/EBPδ APRE. The sequences were aligned through the core palindromic TT-AA motif (boldface). In cases where there is more than one possibility for the -AA motif, the alternative bases are boldface and underlined.
b
Binding (+) or lack of binding (−) of each SBE to Stat1 and Stat3, as determined by use of specific antibodies in supershift assays. ND, not determined.