REAGENT or RESOURCE	SOURCE	IDENTIFIER
Biological samples
Human blood, urine and fecal samples	This study	N/A
Omniplasma	Sanquin	https://prothya.com/product/omniplasma/
Chemicals, peptides, and recombinant proteins
Bovine Serum Albumin (BSA)	Sigma Aldrich, Schnelldorf, Germany	CAS 9048-46-8
AOV801 Curcumin 600 mg capsules	MCO Health B.V., Almere, The Netherlands	https://www.aov.nl/
AOV811 Curcumin 600 mg plus piperine 5 mg capsules	MCO Health B.V., Almere, The Netherlands	https://www.aov.nl/
NovaSOL®	AQUANOVA AG, Darmstadt, Germany	https://aquanova.de/
Longvida®	Verdure Sciences, Noblesville, U.S.A.	https://vs-corp.com/longvida/
Dimethyl sulfoxide	Sigma Aldrich, Schnelldorf, Germany	CAS 67-68-5
Methanol ≥99.9%, MS	Sigma Aldrich, Schnelldorf, Germany	CAS 67-56-1
β-glucoronidase from Helix Pomatia, Type H-1	Sigma Aldrich, Schnelldorf, Germany	CAS 9001-45-0
tert-butyl methyl ether (TBME)	Sigma Aldrich, Schnelldorf, Germany	CAS 1634-04-4
curcumin (≥98% HPLC)	Sigma-Aldrich, St. Louis, MOI, USA	CAS 458-37-7
Demethoxycurcumin (≥98% HPLC)	Sigma-Aldrich, St. Louis, MOI, USA	CAS 22608-11-3
Bisdemethoxycurcumin (≥98% HPLC)	Sigma-Aldrich, St. Louis, MOI, USA	CAS 33171-05-0
Piperine (analytical standard)	Sigma-Aldrich, St. Louis, MOI, USA	CAS 94-62-2
Tetrahydrocurcumin (≥98% HPLC)	Toronto Research Chemicals (Toronto, Canada)	CAS 3606-04-1
Curcumin-D6	Toronto Research Chemicals (Toronto, Canada)	CAS 1246833-26-0
(2E)-demethoxycurcumin-d7	Toronto Research Chemicals (Toronto, Canada)	CAS 22608-11-3
(E,E)Bisdemethoxycurcumin-D8	Toronto Research Chemicals (Toronto, Canada)	CAS 33171-05-0
Tetrahydrocurcumin-D6	Toronto Research Chemicals (Toronto, Canada)	CAS 1794898-13-7
Piperine-D10	Toronto Research Chemicals (Toronto, Canada)	CAS 94-62-2
Software and algorithms
GraphPad Prism, version 10.2.0	GraphPad Software, La Jolla California, USA	https://www.graphpad.com
Analyst®, versions 1.6.2 and 1.7.2	Sciex, Framingham, MA, USA	https://sciex.com/
Other
JumboMix 3500 P CC	Interscience, Saint Nom la Bretèche, France	https://www.interscience.com/
API 4000 triple mass spectrometer	Sciex, Framingham, MA, USA	https://sciex.com/
UltiMate 3000 LC System	Dionex, Sunnyvale, CA, USA	https://www.thermofisher.com/
3.5 micron ZORBAX Extend-C18 particles	Agilent, Santa Clara, CA, USA	https://www.agilent.com/
4.0 × 2.0 mm Securityguard C18 pre-column	Phenomex, Utrecht, The Netherlands	https://www.phenomenex.com/