REAGENT or RESOURCE	SOURCE	IDENTIFIER
Antibodies
Rabbit anti-AIF polyclonal antibody	R&D Systems	Cat# AF1457, RRID: AB_2224516
Mouse anti-cytochrome-c monoclonal antibody	BD Biosciences	Cat# 556432, RRID: AB_396416
Mouse anti-GAPDH monoclonal antibody (clone 6C5)	Millipore	Cat# MAB374 RRID: AB_2107445
Rabbit anti-GAPDH polyclonal antibody	Yamaji et al. 2003, https://www.sciencedirect.com/science/article/pii/S016748890200397X?via%3Dihub	N/A
Mouse anti-glial fibrillary acidic protein (GFAP) monoclonal antibody (Clone 6F2)	Agilent Technologies (DAKO)	Cat# M0761 RRID: AB_2109952
Rabbit anti-H2B polyclonal antibody	Sigma-Aldrich (Upstate)	Cat# SAB4503276 RRID: AB_10747200
Rabbit anti-MAP2 rabbit polyclonal antibody	Millipore	Cat# AB5622 RRID: AB_91939
Rabbit anti-myc polyclonal antibody (A-14)	Santa Cruz Biotechnology	Cat# sc-789 RRID: AB_631274
Rabbit anti-myc monoclonal antibody (Clone 9E10)	Santa Cruz Biotechnology	Cat# sc-40 RRID: AB_627268
Mouse anti-NeuN monoclonal antibody (Clone A60)	Millipore	Cat# MAB377 RRID: AB_2298772
Rabbit anti-TPI polyclonal antibody	Yamaji et al. 2003, https://www.sciencedirect.com/science/article/pii/S016748890200397X?via%3Dihub	N/A
Mouse anti-CIV (OxPhos Complex IV) monoclonal antibody (Clone 1D6E1A8)	Invitrogen	Cat# 459600 N/A
Secondary (western blotting): goat anti-mouse IgG (H + L), HRP-conjugated	BIO-RAD	Cat #172-1011 RRID: AB_11125936
Secondary (western blotting): goat anti-rabbit IgG (H + L), HRP-conjugated	BIO-RAD	Cat #172-1019 RRID: AB_11125143
Secondary (immunohistochemistry): donkey anti-mouse IgG, Alexa-Fluor 488	Thermo Fisher Scientific (Invitrogen)	Cat # A32723 RRID: AB_2633275
Secondary (immunohistochemistry): donkey anti-mouse IgG, Alexa-Fluor 568	Thermo Fisher Scientific (Invitrogen)	Cat# A10037 RRID: AB_11180865
Secondary (immunohistochemistry): donkey anti-rabbit IgG, Alexa-Fluor 488	Thermo Fisher Scientific (Invitrogen)	Cat# A32790 RRID: AB_2762833
Secondary (immunohistochemistry): donkey anti-rabbit IgG, Alexa-Fluor 568	Thermo Fisher Scientific (Invitrogen)	Cat# A10042 RRID: AB_2534017
Bacterial and virus strains
W3CG (K5 strain)	Ganter et al. 1990, https://doi.org/10.1021/bi00492a013	N/A
pTRE2	Clontech (TAKARA)	https://www.addgene.org/vector-database/4412/ Cat#6241-1
pTRE2-GAPDH-C152A	Present study	N/A
pAAV-FtTA	Hikida et al. 2010, https://doi.org/10.1016/j.neuron.2010.05.011	N/A
pAAV-MCS	Agilent Technologies	Cat #240071
pAAV-RS	Agilent Technologies	Cat #240071
pHelper	Agilent Technologies	Cat #240071
tTA-AAV2	Hikida et al. 2010, https://doi.org/10.1016/j.neuron.2010.05.011	N/A
pBAD-HisA	Thermo Fisher Scientific (Invitrogen)	Cat # V430-01
pBAD-HisA-human GAPDH	Nakajima et al. 2009, https://doi.org/10.1074/jbc.M109.027698	N/A
pBAD-HisA-mouse GAPDH	Nakajima et al. 2015, https://doi.org/10.1074/jbc.M114.635607	N/A
pBAD-HisA-human C152A-GAPDH	Nakajima et al. 2009, https://doi.org/10.1074/jbc.M109.027698	N/A
Chemicals, peptides, and recombinant proteins
Doxycycline (Dox)	Sigma-Aldrich	Cat # D3447
2,3,5-Triphenyl tetrazolium chloride (TTC)	Sigma-Aldrich	Cat # T8877
4′,6-Diamidino-2-phenylindole dihydrochloride (DAPI)	DOJINDO	Cat # D523
Protease inhibitor cocktail	Thermo Fisher Scientific (Roche)	Cat # 11836145001
Blocking One	Nakalai Tesque	Cat # 03953-95
Isoflurane	DS Pharm	Cat # 59272
Paraformaldehyde	MERK-Sigma-Aldrich	Cat # 158127
NOR3	DOJINDO	Cat # N390
Fluorescence Mounting Medium	Agilent Technologies (Dako)	Cat # S3023
Deprenyl	Fujimoto Pharmaceutical Co. Ltd.	N/A
Experimental models: Organisms/strains
Mouse (M. musculus), C57BL/6J	Jackson Laboratory	JAX: 000664 RRID:IMSR_JAX:000664
C57BL/6J C152A-Tg mice	Present study	N/A
C57BL/6J C152A-Tg strain 2 mice	Present study	N/A
Oligonucleotides
C152A (mutagenesis) sense 5′-ATCAGCAATGCCTCCGCCACCACCAAC-3′	Present study	N/A
C152A (mutagenesis) antisense 5′-GTTGGTGGTGGCGGAGGCATTGCTGAT-3′	Present study	N/A
pBAD-HisA sequencing primer (forward) 5′- ATGCCATAGCATTTTTATCC -3′	Thermo Fisher Scientific (Invitrogen)	Cat #V430-01
pBAD-HisA sequencing primer (reverse) 5′- GATTTAATCTGTATCAGG -3′	Thermo Fisher Scientific (Invitrogen)	Cat #V430-01
pTRE2 sequencing primer (forward) 5′-GACCTCCATAGAAGACACCG-3′	Clontech (TAKARA)	Cat# 6241-1
pTRE2 sequencing primer (reverse) 5′-TACAAGGGACATCTTCCCATTC-3′	Clontech (TAKARA)	Cat# 6241-1
Primer-A forward (genotyping) 5′-GGTACCCGGGTCGAGGTAGGCGTGT-3′	Present study	N/A
Primer-A reverse (genotyping) 5′-GAATTCGGGGCCGCGGAGGCT-3′	Present study	N/A
Primer-B forward (genotyping) 5′-CCGTCAGATCGCCTGGAGACGCCAT-3′	Present study	N/A
Primer-B reverse (genotyping) 5′-TGGTGACCAGGCGCCCAATACGACC-3′	Present study	N/A
Recombinant DNA
pTRE2-C152A-GAPDH-myc	Present study	N/A
Cells
PC12	ATCC	Cat# CRL-1721 RRID:CVCL_0481
Deposited data
Mendeley data	Present study	https://doi.org/10.17632/r63n4pk94p.3
Critical commercial assays
QuickChange Site-Directed Mutagenesis Kit	Agilent (Stratagene)	Cat # 200518
QIAquick Gel Extraction Kit	Qiagen	Cat # 28706
Lipofectamine 2000 Transfection Reagent	Thermo Fisher Scientific (Invitrogen)	Cat # 11668019
VIRA TRAP AAV Purification Kit	Omega Bio-Tek	Cat #V1169-00
AAV2 Titration ELISA Kit	Progen	Cat # PRATV
Pierce™ BCA Protein Assay Kits	Thermo Fisher Scientific (Pierce)	Cat # 23225
Pierce™ ECL Plus Western Blotting Substrate	Thermo Fisher Scientific (Pierce)	Cat # 32132
CellTiter-Glo® Luminescent Cell Viability Assay	Promega	Cat #G7573
Software and algorithms
AutoDock Vina	The Scripps Research Institute	https://vina.scripps.edu RRID:SCR_011958
Ligplot+	European Bioinformatics Institute	https://www.ebi.ac.uk/thornton-srv/software/LigPlus/RRID:SCR_018249
Pymol 3.0	Schrödinger	https://pymol.org RRID:SCR_000305
GraphPad Prism 10.2.2	GraphPad Software	RRID:SCR_002798
BioRender (Preparation of Graphical Abstract)	© 2024 BioRender.	https://www.biorender.com/RRID: SCR_018361
ImageJ 1.51j8 (western blotting, TTC)	Wayne Rasband, NIH	http://imagej.nih.gocij RRID:SCR_003070
SoftMax® Pro software	Molecular Devices Japan	https://www.moleculardevices.com/products/microplate-readers/acquisition-and-analysis-software/softmax-pro-software RRID:SCR_014240
EZ-C1 Free viewer Gold Version 3.90 (immunohistochemistry)	Nikon	RRID:SCR_014277
Multigauge (western blotting)	FUJI-FILM	RRID:SCR_014299
Other
GAI-1	Itakura et al.53, https://doi.org/10.1016/j.bbrc.2015.09.150.	N/A
GAI-2	Present study	N/A
GAI-3	Present study	N/A
GAI-4	Present study	N/A
GAI-5	Present study	N/A
GAI-6	Present study	N/A
GAI-7	Present study	N/A
GAI-8	Present study	N/A
GAI-9	Present study	N/A
GAI-10	Present study	N/A
GAI-11	Present study	N/A
GAI-12	Present study	N/A
GAI-13	Present study	N/A
GAI-14	Present study	N/A
GAI-15	Present study	N/A
GAI-16	Present study	N/A
GAI-17	Present study	N/A
GAI-18	Present study	N/A
GAI-19	Present study	N/A
GAI-20	Present study	N/A
GAI-21	Present study	N/A
GSH	Sigma-Aldrich	Cat #G4251