Table 1.
Metabolic parameters in C57BL/6 mice after 3 weeks of MCD diet feeding. Mice on MCD diet were treated with vehicle (Control), S1 or liPS peptides at the doses indicated (nmol/g body weight). Normal diet (ND) was used as reference group. Mean ± SD of the indicated number of animals per group. aP<0.05 vs ND; bP < 0.05 vs Control. Abbreviations: BW, body weight; LW, liver weight; LW/BW, relative liver-to-body weight; BG, blood glucose; ALT, alanine aminotransferase; AST, aspartate aminotransferase; Chol, total cholesterol; TG, triglycerides.
| 3wk MCD |
||||||
|---|---|---|---|---|---|---|
| ND (n = 8) | Control (n = 8) | S1-0.6 (n = 5) | S1-1.2 (n = 7) | liPS-0.6 (n = 5) | liPS-1.2 (n = 7) | |
| Initial BW (g) | 29.0 ± 1.3 | 30.0 ± 1.5 | 29.7 ± 1.0 | 29.3 ± 1.1 | 31.6 ± 1.4 | 30.1 ± 0.8 |
| Final BW (g) | 29.6 ± 1.2 | 20.1 ± 1.3a | 20.9 ± 0.2a | 21.6 ± 0.9a | 19.7 ± 1.1a | 21.1 ± 0.9a |
| LW (g) | 1.82 ± 0.08 | 0.94 ± 0.20a | 1.08 ± 0.17a | 1.28 ± 0.08a,b | 1.10 ± 0.12a | 1.25 ± 0.12a,b |
| LW/BW (g/g) | 0.061 ± 0.002 | 0.047 ± 0.010a | 0.052 ± 0.008 | 0.059 ± 0.004b | 0.056 ± 0.008 | 0.060 ± 0.006b |
| BG (mg/dL) | 136.4 ± 15.9 | 73.5 ± 4.9a | 93.8 ± 3.9a | 94.7 ± 5.8a,b | 97.8 ± 17.7a,b | 92.6 ± 14.9a,b |
| ALT (IU/L) | 41.8 ± 9.5 | 299.1 ± 31.1a | 229.5 ± 32.7a,b | 177.2 ± 43.7a,b | 234.2 ± 41.0a,b | 188.8 ± 24.5a,b |
| AST (IU/L) | 60.1 ± 17.6 | 236.6 ± 35.3a | 191.4 ± 22.5a,b | 151.4 ± 20.8a,b | 187.1 ± 16.1a,b | 170.6 ± 27.3a,b |
| Chol (mg/dL) | 137.0 ± 16.5 | 47.4 ± 13.2a | 62.7 ± 11.1a | 78.6 ± 12.7a,b | 70.2 ± 9.9a | 84.8 ± 17.3a,b |
| TG (mg/dL) | 108.3 ± 9.9 | 44.4 ± 8.0a | 58.6 ± 7.5a | 63.9 ± 10.5a,b | 71.8 ± 7.9a,b | 60.9 ± 12.8a,b |