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. 2025 May 14;4(6):101786. doi: 10.1016/j.jacadv.2025.101786

Table 2.

Baseline Data of Included Patients

First Author, Year Study Arms Age, y BMI,
kg/m2 		Male Statins Years of Exercise Exercise Duration/wk, h MET-Hours Per Week Resting Heart Rate, beats/min Systolic BP, mm Hg Diastolic BP, mm Hg Total Cholesterol, mg/dL LDL Cholesterol, mg/dL Hyperlipidemia Cholesterol, mg/dL
Aengevaeren, 2017 <1,000 MET-min/wk, 88 (30.99) 54.4 ± 6.1 25.3 ± 2.9 88 (100) 6 (7) 25.67 ± 13.1 1.43 ± 0.75 10.43 ± 5.05 NR 128 ± 11 80 ± 8 207.27 ± 33.64 NR NR
1,000-2,000 MET-min/wk, 121 (42.61) 54.8 ± 6.3 24.8 ± 2.8 121 (100) 2 (2) 35.67 ± 8.25 3 ± 0.9 23.93 ± 6.08 130 ± 15 80 ± 9 205.34 ± 34.03
<2,000 MET-min/wk, 75 (89.29) 55.9 ± 6.9 24.5 ± 2.3 75 (100) 7 (9) 40.67 ± 9.07 5.867 ± 2.041 47.467 ± 15.57 129 ± 12 80 ± 8 210.36 ± 37.12
Bachman, 2020 ≥3,000 MET-min/wk, 25 (58.14) 50 ± 1 21.6 ± 0.4 14 (56) NR 19 ± 2 11.5 ± 0.6 123 ± 7 46 ± 1 111 ± 2 76 ± 1 204.95 ± 7.734 119.877 ± 7.734 69.61 ± 3.867
<1,500 MET-min/wk, 18 (41.86) 49 ± 2 25.0 ± 0.9 9 (50) NR 5.3 ± 0.5 25 ± 3 53 ± 2 110 ± 2 75 ± 2 193.35 ± 7.734 100.542 ± 7.734 77.34 ± 3.867
Bosscher, 2023 Lifelong Ex, 191 (34.23) 56 ± 7.47 23.23 ± 1.87 191 (100) None 36.33 ± 11.2 11.67 ± 2.99 87.83 ± 21.66 54 ± 7.47 122.33 ± 12.7 75 ± 7.47 192.67 ± 29.13 121.67 ± 25.4 64.33 ± 14.19
Controls, 176 (31.54) 55 ± 7.47 24.06 ± 2.24 176 (100) 10.33 ± 19.4 1.33 ± 2.24 14.3445 ± 10.639 61.33 ± 11.96 123 ± 11.96 75.33 ± 7.47 194.33 ± 34.38 129.67 ± 31.39 57.67 ± 12.71
DeFina, 2019 <1,500 MET-min/wk, 16,447 (75.59) 51.76 ± 8.45 28.25 ± 4.26 16,447 (100) 2,936 (17.85) 18.59 ± 13.82 1.74 ± 2.12 7.72 ± 7.83 NR 124.9 ± 14.28 NR 198.368 ± 37.68 122.72 ± 33 48.12 ± 12.375
1,500-2,999 MET-min/wk,
3,750 (17.24)		 51.167 ± 8.1 27.27 ± 3.57 3,750 (100) 589 (15.71) 23.52 ± 14.02 5.65 ± 2.84 34.67 ± 6.97 24.3 ± 14.13 195.65 ± 35.45 120.34 ± 31.23 51.867 ± 13.36
≥3,000 MET-min/wk, 1,561 (7.17) 52.46 ± 8.56 27.1 ± 3.63 1,561 (100) 245 (15.7) 26.8 ± 14.55 12.13 ± 7.32 77.1 ± 39.43 124.64 ± 13.91 195.31 ± 35.79 119.59 ± 31.87 53.2 ± 13.7
Merghani, 2017 Athletes, 152 (62.3) 54.4 ± 8.5 NR 106 (69.74) NR 31 ± 12.6 7.56 ± 3.54 NR NR 125.65 ± 10.26 78.34 ± 7.63 175.56 ± 16.24 110.98 ± 14.31 NR
Controls, 92 (37.7) 53.43 ± 7.92 54 (35.53) NR 1.9 ± 0.34 123.58 ± 8.64 78.18 ± 6.9 171.69 ± 13.9 112.143 ± 11.52
Mohlenkamp, 2008 Marathon runners, 108 (9.09) 57.2 ± 5.7 24.0 ± 2.3 108 (100) NR NR NR 78.1 ± 38.08 65 ± 10 121 ± 14 NR 227 ± 42 121 ± 29 73.8 ± 17.3
Age and RFs matched controls, 216 (18.18) 57.1 ± 5.6 24.9 ± 2.1 216 (100) 29.13 ± 36.67 74 ± 11 127 ± 14 215 ± 32 131 ± 31 60.6 ± 14.7
Roberts, 2017 Marathon runners, 26 (48.15) 56 ± 10 22 ± 3 0 NR At least 10 NR NR 57.1 ± 7.6 120 ± 13 78 ± 10 189.4 ± 31.9 103 ± 23 73 ± 15
Controls, 28 (51.85) 61 ± 10 32 ± 8 0 NR 72.2 ± 12.1 130 ± 21 75 ± 11 198.9 ± 32.3 119 ± 36 54 ± 16
Schwartz, 2014 Marathon runners, 50 (68.49) 59.44 ± 6.66 24.16 ± 2.88 50 (100) NR At least 25 NR NR 52.36 ± 9.31 127.02 ± 13.74 79.04 ± 9.4 186.44 ± 28.83 111.90 ± 26.09 58.02 ± 11.58
Controls, 23 (31.51) 55.43 ± 10.39 30.29 ± 5.16 23 (100) 70.83 ± 10.57 134.00 ± 18.35 79.3 ± 10.39 183.56 ± 48.59 108.13 ± 45.23 46.67 ± 8.86
Pavlovic, 2024 <1,500 MET-min/wk, 4,245 (18.15) 53 ± 8.7 28.8 ± 4.6 2,491 (58.68) 786 (18.5) NR Zero <25, 4,245 (100) NR 126.1 ± 14.6 NR 200.4 ± 38 124.4 ± 33.2 47.1 ± 12.6
1,500-3,000 MET-min/wk, 9,115 (38.39) 50.4 ± 7.9 27.5 ± 3.7 6,129 (67.24) 1,470 (16.1) 3.09 ± 0.83
  • 1.

    <25, 4,867 (53.4)

  • 2.

    25-50, 2,878 (31.6)

  • 3.

    ≥50, 1,370 (15)

 123.1 ± 13.4 196.1 ± 36.2 121 ± 32.2 51.1 ± 13.1
≥3,000 MET-min/wk, 2,227 (9.52) 48.3 ± 6.6 26 ± 2.9 1,991 (89.4) 252 (11.3) 8.075 ± 4.38
  • 1.

    <25, 1,288 (57.8)

  • 2.

    25-50, 731 (32.8)

  • 3.

    ≥50, 208 (9.3)

 122.2 ± 12.9 198 ± 35.7 121.9 ± 31.6 54.2 ± 13.4

Values are n (%) or mean ± SD.

BMI = body mass index; BP = blood pressure; LDL = low-density lipoprotein; other abbreviations as in Table 1.