Table 2.

Baseline characteristics of wild-type and global Tmem86b knockout mice

Parameter	WT	Het KO	Hom KO
Body weight (g)	26.02 ± 0.41	26.88 ± 0.54	27.43 ± 0.66
Liver weight (g)	1.24 ± 0.02	1.22 ± 0.04	1.20 ± 0.04
FBG (mmol/L)	10.36 ± 0.66	9.98 ± 0.45	9.10 ± 0.52
TG (mmol/L)	0.64 ± 0.08	0.49 ± 0.09	0.85 ± 0.07
COH (mmol/L)	1.71 ± 0.08	1.69 ± 0.15	1.51 ± 0.10
HDL-C (mmol/L)	1.58 ± 0.07	1.53 ± 0.12	1.31 ± 0.11
ALT (U/L)	17.80 ± 1.40	20.02 ± 3.35	20.40 ± 1.25
AST (U/L)	92.75 ± 20.81	79.63 ± 9.00	118.81 ± 22.02

Data are presented as mean ± SEM (12-week-old male mice, n = 4–7/group); ALT, alanine aminotransferase; AST, aspartate aminotransferase; COH, free cholesterol; FBG, fasting blood glucose; HDL-C, high-density lipoprotein cholesterol; Het KO, heterozygous knockout; Hom KO, homozygous knockout; TG, triglyceride; WT, wild-type.

The mean differences between the groups (wild-type and knockout) were analyzed using one way ANOVA followed by Tukey’s HSD post hoc test.