Table 7. A list of therapeutics, targeting various miRNAs in some important types of cancer.
| Therapeutics | Cancer | Target miRNA | Mechanism of action |
|---|---|---|---|
| Metformin | Pancreatic cancer, Prostate cancer, breast cancer | miR-34a, miR-21, miR-145, miR-101 | Targeting glucose metabolism |
| Pegylated arginine deiminase | Pancreatic cancer | miR-1291 | Targeting glutamine metabolism |
| AZD3965 | Breast cancer | miR-342-3 | Targeting lactate metabolism: LDHA inhibitors |
| 5-Fluorouracil | Hepatocellular carcinoma, |
miR-210, miR-122 | Antimetabolite chemotherapeutic agents |
| Gemcitabine | Pancreatic cancer | miR-218 | Inhibits the secretion of HMGB1 |
| Rapamycin | Renal cancer | miR-21 | Targeting fatty acid metabolism |
Note: *Adapted from [200]and modified.