| Venetoclax and azacytidine |
Suppression of oxidative phosphorylation induces leukemia stem cell death |
Acute myeloid leukemia |
[203,204] |
| Dichloroacetic acid |
Inhibits the TCA cycle |
Liver cancer |
[205] |
| Rapamycin |
Inhibits tumor formation |
Various cancers |
[206,207] |
| MitoTEMPOL |
Antioxidant (reducing ROS) |
Various cancers |
[208] |
| IACS-010759 |
inhibits proliferation and induces apoptosis |
Brain tumor |
[209] |
| Gboxin |
Complex V inhibitor |
Glioblastoma |
[210] |
| Metformin |
Complex I inhibitor |
Breast cancer, Colon cancer |
[211] |
| Deguelin |
Complex I inhibitor |
Melanoma |
[212] |
| Rotenone |
Complex I inhibitor |
Various cancers |
[213] |
| Tigecycline |
Mitochondria protein translation inhibitor |
Various cancers |
[214] |
| Atovaquone |
Inhibits mitochondrial complex III |
Non-small cell lung cancer |
[215] |
| Gamitrinib |
OXPHOS assembly inhibitor |
Various cancers |
[216] |
| Enasidenib |
IDH2-mutant inhibitor |
Acute myeloid leukemia |
[217] |
