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The PAK inhibitor can block effects of constitutively active PAK in vivo. The effects of microinjected αPAKL107F on HeLa cells (arrows) include cell retraction (a) seen in cells stained for expressed PAK, loss of actin stress fibers (b), and dissolution of paxillin-stained focal adhesions (c). All three effects could be blocked by coinjection of an expression construct encoding αPAK83-149 (arrowheads).
