Table 1.

Clinical and genotype data from affected and unaffected members of the Parkinson’s family

FAMILY MEMBER	AGE AT DIAGNOSIS	YEARS OF EVOLUTION	RT	MF	D	PS	CI	NI	GENETIC FINDINGS
II.6 (†)	57	29	Yes	Yes	Yes	Yes&	Mild dementia	DaTSCANΩ MRI: normal	LRRK2: p.[Leu119Pro; p.Leu488Pro] GBA1: del exon4-exon 11
II.3 (†)	73	14	Yes	No	No	–	Dementia	–	*
II.7	NA	NA	No	No	No	No	NA	–	None
II.8	75	11	Yes	No	No	No	No	DaTSCANΩ	LRRK2: p.[Leu119Pro; p.Leu488Pro]
III.4	57	7	Yes	Yes	Yes	Yes	Mild Cognitive Impairment	DaTSCANΩ MRIΩ	LRRK2: p.[Leu119Pro; p.Leu488Pro] GBA1: del exon4-exon 11
III.1	NA	NA	No	No	No	No	NA	–	None
III.6	NA	NA	No	No	No	No	NA	–	GBA1: del exon4-exon 11
III.9	NA	NA	No	No	No	No	NA	–	LRRK2: p.[Leu119Pro; p.Leu488Pro] GBA1: del exon4-exon 11
III.10	NA	NA	No	No	No	No	NA	–	LRRK2: p.[Leu119Pro; p.Leu488Pro] GBA1: del exon4-exon 11

NA not applicable, RT resting tremor, MF motor fluctuation, D Dyskinesias, PS psychotic symptoms, NI neuroimaging studies, DaTScan single photon emission computed tomography with Ioflupane I123 injection, DaTScan^Ω showed a decrease in the uptake of the radiotracer in the putamen, MRI magnetic resonance imaging, MRI^Ω small hyperintense lesions in white matter

^&After pharmacological treatment CI cognitive impairment

^*Obligatory carrier of LRRK2: p.[Leu.119Pro; p.Leu488Pro] and GBA: del exon4-exon 11