Table 2.
Characteristics of studies included in meta-analysis
| First author | Year | Study Design | Region | Observation Period | Sample size | Measurements of diabetes |
|---|---|---|---|---|---|---|
| Franchi et al. | 2001 | Cross-sectional study | Italy | 1989–1999 | 455 | Diagnosed and treated by their primary care physician |
| Molina-Cabrillana et al. | 2008 | Prospective study | Spain | 2000–2004 | 1,540 | NR |
| Lake et al. | 2013 | Cross-sectional study | USA | 2005–2009 | 13,822 | ICD-9-CM diagnoses codes |
| Mahdi et al. | 2014 | Retrospective study | USA | 2005–2011 | 28,366 | ICD-9-CM diagnoses codes |
| Catanzarite et al. | 2015 | Retrospective study | USA | 2011–2012 | 21,228 | ICD-9-CM diagnoses codes |
| Jennings et al. | 2015 | Prospective study | USA | 2011–2012 | 36,941 | ICD-9-CM diagnoses codes |
| Tuomi et al. | 2016 | Retrospective study | Finland | 2007–2013 | 912 | NR |
| Jiamset et al. | 2016 | Retrospective study | Thailand | 2001–2014 | 444 | Diagnosed and treated by their primary care physician |
| Laughlin-Tommaso et al. | 2016 | Retrospective study | USA | 1965–2002 | 7632 | Electronic codes of the Mayo Clinic Study of Uterine Disease and Health |
| Penn et al. | 2017 | Retrospective study | USA | 2013–2015 | 2,068 | ICD-9-CM diagnoses codes |
| Agrawal et al. | 2018 | Prospective study | USA | 2006–2015 | 157,589 | ICD-9-CM diagnoses codes |
| Corrigan et al. | 2019 | Prospective study | USA | 2007–2016 | 56,640 | ICD-9-CM diagnoses codes |
| Liang et al. | 2020 | Prospective study | China | 2004–2011 | 431 | HbA1c > 7.0% |
| Slavchev et al. | 2021 | Retrospective study | Bulgaria | 2004–2012 | 104 | Diagnosed and treated by their primary care physician |
| Ringel et al. | 2021 | Retrospective cohort study | USA | 2012–2017 | 41,286 | HbA1c ≥ 6.5% |
| Mauney et al. | 2022 | Cross-sectional study | USA | 2015–2017 | 5,098 | ICD-9-CM diagnoses codes |
| Bing et al. | 2022 | Retrospective study | China | 2011–2021 | 48 | Diagnosed and treated by their primary care physician |
| Boyles et al. | 2022 | Retrospective study | USA | 2015–2019 | 739 | NR |
| Wang et al. | 2022 | Retrospective study | China | 2013–2021 | 188 | Diagnosed and treated by their primary care physician |
| First author | Diabetes definition | Type of hysterectomy | Outcomes | Follow-up period | Adjusted variables |
|---|---|---|---|---|---|
| Franchi et al. | Diagnosed and treated by their primary care physician | Abdominal hysterectomy | Incisional hernia | 5 Years | Severe wound infection; Body mass index > 27 kg/m2; Age > 62 y; Fascial closure with interrupted suture |
| Molina-Cabrillana et al. | NR | Abdominal hysterectomy; Vaginal hysterectomy | SSI | NR | NR |
| Lake et al. | Identified from ICD-9 discharge diagnoses | Laparotomy; Total vaginal hysterectomy; Laparoscopy | Cellulitis(SSI) | 1 Month | Route of hysterectomy; Operative time > 75th percentile duration; American Society of Anesthesiologists class 3; Body mass index |
| Mahdi et al. | Identified from ICD-9 discharge diagnoses | Abdominal hysterectomy; Laparoscopic hysterectomy; | SSI | 1 Month | Smoking; Respiratory risk factors; Overweight; American Society of Anesthesiologists class > 3; Blood transfusion; Operative time > 180 min; Creatinine concentration > 2 mg/dL; Serum albumin concentration < 3 mg/dL |
| Catanzarite et al. | Identified from ICD-9 discharge diagnoses | Laparoscopic-assisted vaginal hysterectomy; Laparoscopic hysterectomy; Vaginal hysterectomy | Readmission | 1 Month | Age; Obesity; Smoking; Steroid use; Dyspnea; Hypertension; COPD; Prior surgery > 30 days; Bleeding disorders; ASA class 3 or 4; Type of hysterectomy; Inpatient status; LOS |
| Jennings et al. | Identified from ICD-9 discharge diagnoses | Total laparoscopic; Laparoscopic-assisted vaginal; Supracervical hysterectomies | Readmission | 1 Month | NR |
| Tuomi et al. | NR | Minimally invasive hysterectomy; Traditional laparoscopy hysterectomy | SSI | 1 Month | Body mass index; Current smoking; Leukocytosis; Minimally invasive surgery; Operative time; Estimated blood loss |
| Jiamset et al. | Diagnosed and treated by their primary care physician | Radical hysterectomy | Hemorrhage > 1,500 mL; Blood transfusion; Vascular injury; Postoperative morbidity Febrile morbidity; Urinary tract infection; Vaginal stump infection; Wound infection;5-Year overall survival | 5 Years | Age; Node metastasis |
| Laughlin-Tommaso et al. | Identified from the Mayo Clinic Study of Uterine Disease and Health | NR | Cardiovascular diseases | 3 Years | Hyperlipidemia; Hypertension; Obesity; Metabolic syndrome; Polycystic ovary syndrome |
| Penn et al. | Identified from ICD-9 discharge diagnoses | NR | Readmission | 1 Month | NR |
| Agrawal et al. | Identified from ICD-9 discharge diagnoses | Minimally invasive hysterectomy; Abdominal hysterectomy; Vaginal hysterectomy | Extended LOS | 1 Month | Year of operation; Age; Race; Body mass index; Functional status; Chronic obstructive pulmonary disease; Bleeding disorder; Intraoperative conditions; Postoperative conditions |
| Corrigan et al. | Identified from ICD-9 discharge diagnoses | Total laparoscopic hysterectomy; Laparoscopic-assisted vaginal hysterectomy; Laparoscopic supracervical hysterectomy | Superficial surgical site wound infection; Reintubation; Failure to wean; Myocardial infarction; Extended LOS; Pneumonia; Renal insufficiency; Renal failure; Urinary tract infection; Myocardial infarction; Transfusion; Sepsis | 1 Month | NR |
| Liang et al. | According to American Diabetes Association diagnostic criteria or a patient-reported history of diabetes | NR | 5-year survival | 5 Years |
Age; BMI; Serum creatinine; Tumor stage Histology; Tumor differentiation; Tumor size; Deep stromal invasion; LVSI; Hypertension; Cardiovascular disease |
| Slavchev et al. | Diagnosed and treated by their primary care physician | Radical hysterectomy; Total hysterectomy | 5-year survival | 5 Years | Age; Ascites; Type of surgery; Residual tumor size; LN metastasis; Performance status |
| Ringel et al. | Managed for > 2 weeks before surgery | NR | Readmission; ED visit; Reoperation; Acute renal injury; Pneumonia; Superficial surgical site infection; Deep surgical site infection; Organ space surgical site infection; UTI; Cardiac dysfunction; DVT; PE; Severe sepsis; Unplanned intubation; MI; Stroke; Cardiac arrest; Death | 1 Month | NR |
| Mauney et al. | Identified from ICD-9 discharge diagnoses | Peripartum hysterectomy | VTE | 6 Weeks | Hysterectomy; Advanced maternal age; Obesity; Pregnancy-related hypertension; Primary hypercoagulable state; Tobacco use; Multifetal gestation; Peripartum infection |
| Bing et al. | Diagnosed and treated by their primary care physician | NR | Mortality | 5 Years | Age; NLR > 3.0995; MLR > 0.2386; PLR > 154.3309; Tumor stage |
| Boyles et al. | NR | Abdominal hysterectomy | SSI | 1 Month | BMI > 40; Bowel resection; ASA class 3 or 4; Closing tray protocol |
| Wang, D. | Diagnosed and treated by their primary care physician | Abdominal hysterectomy | SSI | NR | NR |
Abbreviations: ASA = American Society of Anesthesiologists; BMI = Body mass index; COPD = Chronic obstructive pulmonary disease; DM = Diabetes mellitus; DVT = Deep venous thrombosis; ED = Emergency department; HbA1c = Glycosylated hemoglobin; IDDM = Insulin-dependent diabetes mellitus; LOS = Length of stay; LVSI = Lymphatic vascular space involvement; LN = Lymph nodes; MI = Myocardial infarction; MLR = Monocyte/lymphocyte ratio; NIDDM = Non-insulin-dependent diabetes mellitus; NLR = Neutrophil/lymphocyte ratio; PE = Pulmonary embolism; PLR = Platelet/lymphocyte ratio; SSI = Surgical site infections; UTI = Urinary tract infection; VTE = Venous thromboembolism