Table 2.
Patient self-reported migraine burden by number of preventive treatment failures.
| Variable | Treatment naïve | 1 Treatment failure | ≥2 Treatment failures | ||
|---|---|---|---|---|---|
| Mean or no. (SD or %) | Mean or no. (SD or %) | p a | Mean or no. (SD or %) | p a | |
| Migraines related to menstrual cycle b | 223 (40.3) | 112 (42.0) | 0.699 | 132 (37.9) | 0.510 |
| Monthly headache days | 9.6 (7.2) | 10.4 (7.2) | 0.140 | 11.7 (7.9) | <0.001 |
| Monthly migraine days | 5.9 (6.0) | 6.7 (6.2) | 0.041 | 7.8 (7.5) | <0.001 |
| MIDAS | 25.5 (35.5) | 28.8 (33.8) | 0.140 | 35.4 (42.4) | <0.001 |
| PHQ-9 | 8.7 (7.2) | 9.7 (6.8) | 0.025 | 10.7 (7.0) | <0.001 |
| GAD-7 | 7.4 (6.2) | 8.0 (5.8) | 0.126 | 8.6 (6.0) | 0.001 |
| RAND-36 GHC | 37.2 (12.2) | 35.5 (11.8) | 0.028 | 34.4 (11.6) | <0.001 |
| RAND-36 PHC | 41.4 (11.3) | 39.3 (11.5) | 0.004 | 38.3 (11.0) | <0.001 |
| RAND-36 MHC | 36.6 (12.5) | 35.6 (11.6) | 0.184 | 34.6 (11.7) | 0.005 |
| EQ-5D | 0.73 (0.17) | 0.71 (0.19) | 0.107 | 0.69 (0.20) | 0.006 |
| Absenteeism | 10.9 (21.4) | 15.1 (24.7) | 0.034 | 18.6 (25.6) | <0.001 |
| Presenteeism | 31.5 (27.6) | 36.2 (28.1) | 0.042 | 39.1 (28.0) | <0.001 |
| Work productivity loss | 34.9 (30.5) | 41.0 (30.7) | 0.019 | 45.9 (31.2) | <0.001 |
| Activity impairment | 36.7 (29.6) | 42.6 (28.6) | 0.002 | 46.8 (30.1) | <0.001 |
| Among employed | 32.5 (28.1) | 37.1 (28.9) | 0.044 | 43.1 (30.2) | <0.001 |
| Among unemployed | 39.4 (29.7) | 48.7 (25.9) | 0.005 | 46.4 (28.9) | 0.029 |
| Among disabled | 66.8 (26.6) | 65.3 (20.1) | 0.804 | 71.9 (19.1) | 0.314 |
a
Compared with treatment naïve. Results are based on the study sample after inverse probability of treatment weighting. p Values are derived from t test (continuous) and Chi-square test (categorical).
b
Female patients only.
EQ-5D, 5-level EuroQoL instrument; GAD-7, the 7-Item Generalized Anxiety Disorder scale; GHC, global health composite score; MHC, mental health composite score; MIDAS, the Migraine Disability Assessment; PHC, physical health composite score; PHQ-9, the 9-Item Patient Health Questionnaire; RAND-36, 36-Item Short Form Survey Instrument; SD, standard deviation.