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. 2025 May 27;122(22):e2503570122. doi: 10.1073/pnas.2503570122

Fig. 2.

Fig. 2.

Effect of VX-548 on action potentials in human DRG neurons. (A) Action potential evoked by a short (0.5-ms) current injection before and after application of 10 nM VX-548. (B) Phase-plane plot of dV/dt versus V showing modest reduction of maximum upstroke velocity and substantial reduction of peak and shoulder. Upper dashed lines: maximum upstroke velocity in control (black) and with 10 nM VX-548 (red). (C) Collected results for effect of 10 nM VX-548 on action potential threshold determined as in SI Appendix, Fig. S3. (D) Collected results for effect of 10 nM VX-548 on peak of the action potential evoked by a short current injection. (E) Collected results for effect of 10 nM VX-548 on the maximal upstroke velocity of the action potential. (F) Collected results for effect of 10 nM VX-548 on the width of the action potential measured at half-maximum amplitude.