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Effect of 10 nM VX-548 on maximal repetitive firing. (A) Firing evoked by 1-s injections of current of increasing magnitude in control and after application of 10 nM VX-548. (B) Number of action potentials as a function of the injected current. (C) Collected results for the effect of 10 nM VX-548 on the maximal number of action potentials during 1-s current injections over a range of magnitudes. Dashed line drawn at 1 action potential.
