Fig. 8.

Additional sodium current component with both Nav1.7 and Nav1.8 inhibited. Action potential clamp experiments were performed as in Fig. 7. (A) Example of a neuron in which a large sodium current remained in the first action potential in the presence of 30 nM VX-548 and 30 nM GsAF-1 and was inhibited by application of 1 µM TTX. (B) Collected results for the different components of sodium current evoked during the 1st, 2nd, and last action potentials in 10 neurons. Asterisks indicate neurons in which only VX-548 and GsAF-1 were applied.