Table 2:
Baseline Patient Characteristics of Studies Included in the Clinical Literature Review, Cluster Headache
| Author, year (study) | Chronic cluster headache,% | Mean age (SD), y | Male, % | Race or ethnicity, % | Mean attack duration (SD), min | Mean no. of attacks in 4 wk (SD) | Preventive medication use, % | Acute medication use, % | ||
|---|---|---|---|---|---|---|---|---|---|---|
| nVNS | Control | nVNS | Control | |||||||
| Gaul et al, 201653 (PREVA) | 100 |
nVNS 45.4 (11.0) Control 42.3 (11.0) |
69.1 | NR |
nVNSa 27.4 (19.8) Controla 29.3 (29.9) |
nVNS 67.3 (43.6) Control 73.9 (115.8) |
Verapamil: 52 Lithium: 13 Topiramate: 15 Corticosteroid: 4 |
Verapamil: 53 Lithium: 18 Topiramate: 14 Corticosteroid: 4 |
Pharmacologic: 90 Oxygen: 67 |
Pharmacologic: 90 Oxygen: 69 |
| Silberstein et al, 201651 (ACT1) | 32.7 |
nVNS 47.1 (13.5) Control 48.6 (11.7) |
84 |
nVNS Asian: 5.5 Black: 6.9 White: 86.3 Missing: 1.4 Control Asian: 1.3 Black: 9.1 White: 88.3 Missing: 1.3 |
nVNS 86 (119) Control 64 (71) |
NR | Overall: 57.5 Verapamil: 15.1 Lithium: 4.1 Topiramate: 2.7 Corticosteroid: 15.1 |
Overall: 77.9 Verapamil: 26 Lithium: 3.9 Topiramate: 9.1 Corticosteroid: 10.4 |
Triptan: 57.5 Oxygen: 42.5 Mild analgesic: 17.8 Narcotic: 5.5 Other: 28.8 None: 5.5 |
Triptan: 70.1 Oxygen: 37.7 Mild analgesic: 20.8 Narcotic: 5.2 Other: 36.4 None: 2.6 |
| Goadsby et al, 201852 (ACT2) | 70.6 |
nVNS 43.9 (10.6) Control 46.9 (10.6) |
71.6 |
nVNS White: 98 Asian: 2 Control White: 100 |
nVNS 69.9 (68.7) Control 77.4 (76.1) |
nVNS 10 (range, 1-53) Control 11 (range 2-39) |
1 or more: 64 Verapamil: 36 Lithium: 8 Corticosteroid: 2 Propranolol: 2 Tricyclic: 4 SRA: 4 Antiepileptic: 20 |
1 or more: 63.4 Verapamil: 44.2 Lithium: 7.7 Corticosteroid: 3.8 Propranolol: 0 Tricyclic: 1.9 SRA: 3.8 Antiepileptic: 11.5 |
Triptan: 74 Oxygen: 54 Mild analgesic: 14 Narcotic: 6 Other: 10 None: 0 |
Triptan: 65.3 Oxygen: 59.6 Mild analgesic: 11.5 Narcotic: 0 Other: 15.4 None: 9.6 |
Abbreviations: NR, not reported; nVNS, noninvasive vagus nerve stimulation; SD, standard deviation; SRA, serotonin receptor antagonist.
a
With acute pharmacologic medications or oxygen treatment.