Table 23:

Mean Change in Pain Score From Baseline to Follow-up for the First Treated Attack, nVNS vs. Control, Acute Treatment, Migraine

Author, year (study)	Time, min	Participants, nVNS/control, n	Mean change from baseline (95% CI)		Mean difference (95% CI)	P
			nVNS	Control
Martelletti et al, 201864 (PRESTO)	120	120/123	-0.62 (NR)	-0.23 (NR)	-0.39 (NE)	.011
	60		-0.51 (NR)	-0.22 (NR)	-0.29 (NE)	.029
	30		-0.34 (NR)	-0.15 (NR)	-0.19 (NE)	.074

Abbreviations: CI, confidence interval; NE, not estimatable; NR, not reported; nVNS, noninvasive vagus nerve stimulation.