Table 25:
Change in Migraine Days From Baseline to Follow-up, nVNS vs. Control, Prevention, Migraine
| Author, year (study) | Participants, nVNS/control, n | Mean change from baseline in migraine days per month (95% CI) | Mean difference (95% CI) | P | |
|---|---|---|---|---|---|
| nVNS | Control | ||||
| Diener et al, 201957 (PREMIUM) | 165/167 | -2.26 (-2.81 to -1.72) | -1.80 (-2.32 to -1.27) | -0.46 (NR)a | .15a |
| Najib et al, 202258 (PREMIUM II) | 56/57 | -3.12 (NR) | -2.29 (NR) | -0.83 (NR)b | .23b |
Abbreviations: CI, confidence interval; NR, not reported; nVNS, noninvasive vagus nerve stimulation.
a
Variance was not calculated because the reported data were adjusted using regression models for treatment group, centre, presence or absence of aura, and number of migraine days at baseline.
b
Adjusted for treatment group, centre, presence of aura, and number of migraine days at baseline.