Table 29:
Mean Change in Acute Medication Days, nVNS vs. Control, Prevention, Migraine
| Author, year (study) | Participants, nVNS/control, n | Mean change in acute medication days from baseline | Mean difference (95% CI) | P a | |
|---|---|---|---|---|---|
| nVNS | Control | ||||
| Diener et al, 2019 (PREMIUM)57 | 165/167 | -1.9 (-2.47 to -1.32) | -1.35 (-1.91 to -0.79) | -0.55 (NR)a | .11 |
| Najib et al, 202258 (PREMIUM II) | 56/57 | -2.53 (NR) | -1.36 (NR) | -1.17 (NR)a | .11 |
Abbreviations: CI, confidence interval; NR, not reported; nVNS, noninvasive vagus nerve stimulation.
a
P values from linear logistic regression adjusted for treatment group, presence of aura, and number of medication days in the run-in period.