Table 3:
Response Within 15 or 30 Minutes, nVNS vs. Control, Acute Treatment, Cluster Headache
| Author, year (study) | Effect measure | Response definition, pain score; time | Participants, nVNS/control, n | Responders, % | Summary estimate | P | |
|---|---|---|---|---|---|---|---|
| nVNS | Control | ||||||
| Silberstein et al, 201651 (ACT1) | Proportion who achieved response after first attack | 0 or 1; 15 min | 60/73 | 26.7 | 15.1 | RR 1.77 (0.89-3.52)a | .1a |
| Goadsby et al, 201852 (ACT2) | Mean proportion of treated attacks per person who achieved response | 0 or 1; 30 min | 48/44 | 42.7 | 27.6 | Absolute difference: 15.1% (SE 7.3) | .05b |
Abbreviations: nVNS, noninvasive vagus nerve stimulation; SE, standard error; RR, relative risk.
a
Calculated in Cochrane RevMan40 using data provided.
b
Adjusted for study site.