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. 2025 May 1;25(2):1–177.

Table 4:

Proportion of People With Sustained Treatment Response After First Attack, nVNS vs. Control, Acute Treatment, Cluster Headache

Author, year (study) Participants, nVNS/control, n Sustained treatment response, %a RR (95% CI)b P
nVNS Control
Silberstein et al, 201651 (ACT1) 60/73 26.7 12.3 2.16 (1.03-4.54) .04

Abbreviations: CI, confidence interval; nVNS, noninvasive vagus nerve stimulation; RR, relative risk.

a

Pain score of 0 or 1 without rescue medication use at 15 to 60 minutes after treatment initiation for the first treated cluster headache attack.

b

Calculated from data provided in the publication.