Table 6:
Pain Intensity, nVNS vs. Control, Acute Treatment, Cluster Headache
| Author, year (study) | Effect measure | Minutes after treatment | Participants, nVNS/control, n | Mean pain intensity (variance) | Mean difference (95% CI)a | P a | |
|---|---|---|---|---|---|---|---|
| nVNS | Control | ||||||
| Silberstein et al, 201651 (ACT1) | Mean pain intensity for all treated attacks, per personb | 15 | 73/60 | 2.1 (95% CI 1.9 to 2.3) | 2.0 (95% CI 1.8 to 2.2) | 0.10 (-0.18 to 0.38) | .48 |
| Goadsby et al, 201852 (ACT2) | Mean change in pain intensity from attack onset to follow-up measurement, per personb | 15 | 36/31 | -1.3 (SE 0.2) | -0.9 (SE 0.1) | -0.40 (-0.84 to 0.04) | .07 |
| 30 | 36/31 | -1.6 (SE 0.2) | -1.2 (SE 0.2) | -0.40 (-0.95 to 0.15) | .16 | ||
Abbreviations: CI, confidence interval; nVNS, noninvasive vagus nerve stimulation; SE, standard error.
a
Calculated from data provided in study.
b
Measured on a scale from 0 to 4 (0 = no pain; 4 = very severe pain).