Table 9:
Mean Duration of First Attack, nVNS vs. Control, Acute Treatment, Cluster Headache
| Author, year (study) | Measure | Subgroup | Participants, nVNS/control, n | Mean duration or mean change (SD), min | Mean difference (95% CI)a | P a | |
|---|---|---|---|---|---|---|---|
| nVNS | Control | ||||||
| Silberstein et al, 201651 (ACT1) | Mean duration of first attackb | Overall | 53/64 | 50.6 (38.3) | 59.9 (47.5) | -9.3 (-24.85 to 6.25) | .24 |
| Episodic | 34/40 | 48.4 (35.4) | 61.2 (49.5) | -12.8 (-32.21 to 6.61) | .20 | ||
| Chronic | 19/24 | 54.5 (43.8) | 57.6 (44.8) | -3.1 (-29.73 to 23.53) | .82 | ||
| Mean change in duration from baseline to first attackb,c | Overall | 41/53 | -9.5 (51.8) | 12.8 (45.5) | -22.3 (-42.34 to -2.26) | .03 | |
| Episodic | 28/36 | -14.4 (59.5) | 16.3 (51.5) | -30.70 (-58.43 to -2.97) | .03 | ||
| Chronic | 13/17 | 1.0 (28.6) | 5.4 (29.2) | -4.4 (-25.24 to 16.44) | .68 | ||
Abbreviations: CI, confidence interval; nVNS, noninvasive vagus nerve stimulation; SD, standard deviation.
a
Calculated from data provided in study.
b
Excluded attacks with a duration of greater than 180 minutes.
c
From the last attack before randomization (based on participant recollection) to the first attack in the randomized phase of the study.